The National Institute of Health awarded a grant to USM for the support of Dr. Hong Xie in her research project The Synergistic Effect and Mechanism of Arsenic on Chromium (VI). The Academic Research Enhancement Award, worth over $400,000, will fund her work for the next three years.
The project focuses on mechanisms of metal-induced carcinogenesis and investigates the hypothesis that arsenic synergistically increases Cr(VI) carcinogenicity as a consequence of interference with the repair of DNA double strand breaks.
An Assistant Research Professor of Toxicology at the Department of Applied Medical Sciences, she received her Ph.D. in Biochemistry and Molecular Biology from the University of Maine. Her thesis focused on metal toxicology and effects of lead chromate in airway epithelium. She completed her Master degree in Toxicology and Occupational Disease in the area of heavy metal renal and liver toxicity at Hunan Medical School in China.
Her research interests are in the areas of heavy metal-induced carcinogenesis focusing on the genomic instability and DNA repair.