The Laboratory uses novel cell culture models and state-of-the-art molecular and toxicological techniques to investigate the effects of metals and particulates on humans and marine animals. In addition, the laboratory uses advanced molecular epidemiological techniques to study gene-environment interactions and to assess individual susceptibility to disease.
The Laboratory is under the direction of Dr. John Pierce Wise, Sr. and includes professional staff, students (graduate, undergraduate and high-school), and volunteers
The Wise Laboratory of Environmental and Genetic Toxicology conducts state-of-the-art research aimed at understanding how environmental toxicants affect the health of humans and marine animals.
This mission is accomplished through the pursuit of the following general objectives:
Conduct innovative and multidisciplinary research in toxicology and molecular epidemiology to further our understanding of disease in humans and marine organisms, particularly as they relate to cancer, asthma and reproductive/developmental effects.
Discover the mechanisms used by metals to turn normal cells into tumor cells, particularly as they relate to genomic instability and DNA repair.
Establish new cell culture models from lung, skin, testis and ovary to investigate how metals and particulates cause cancer, asthma and reproductive/developmental effects in humans and marine organisms.
Study and compare contaminant-induced DNA damage and repair in models of humans and marine organisms.
Determine how environmental contaminant exposure may affect the recovery of critically endangered species including marine mammals, turtles and birds.
Investigate how marine pollution may impact the health of marine invertebrates such as lobsters, oysters, and corals.
Create a national resource and repository of marine cell lines and tissues.