The Wise Laboratory of Environmental and Genetic Toxicology

Publications

(1991-1995 | 1996-2000 | 2001-2005 | 2006-2010 |  2011-2015) Published Abstracts

2011-2015

Holmes, A.L., Joyce, K., Xie, H., Falank, C., Hinz, J.M., and Wise, Sr., J.P. The Impact of Homologous Recombination Repair Deficiency on Depleted Uranium Clastogenicity in Chinese Hamster Ovary Cells: XRCC3 Protects Cells from Chromosome Aberrations, but Increases Chromosome Fragmentation. Mutation Research. In Press.

Savery, L.C., Wise, J.T.F., Wise, S.S., Falank, C., Gianios, Jr., C., Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., and Wise, Sr., J.P. Global Assessment of Arsenic Pollution Using Sperm Whales (Physeter macrocephalus) as an Emerging Aquatic Model Organism. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. In Press.

Wise, S. S., Xie, H., Fukuda, T., Douglas Thompson, W., & Wise, J. P. Hexavalent Chromium Is Cytotoxic and Genotoxic to Hawksbill Sea Turtle Cells. Toxicology and Applied Pharmacology, 279: 113–118, 2014.

Smith, L.J., Holmes, A., Mason, M.D., Zheng, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Soluble and Particulate Cobalt in Human Lung Fibroblast Cells. Toxicology and Applied Pharmacology, 278: 259-265, 2014.

C. Wise, J. Wise, S. Wise, W. Thompson, J. Wise Jr, & J. Wise, Sr. Chemical dispersants used in the Gulf of Mexico oil crisis are cytotoxic and genotoxic to sperm whale skin cells. Aquatic Toxicology 152: 335-340, 2014.

Wise, Jr., J.P., Wise, J., Wise, C., Wise, S., Xie, H., Gianios, Jr., C., Thompson, W.D., Perkins, C., Falank, C., and Wise, Sr., J.P. Concentrations of the Genotoxic Metals, Chromium and Nickel, in Whales, Tarballs, Oil Slicks and Released Oil from the Gulf of Mexico in the Immediate Aftermath of the Deepwater Horizon Oil Crisis:  Is Genotoxic Metal Exposure Part of the Deepwater Horizon Legacy? Environmental Science & Technology. 48(5): 2997–3006 2014. DOI: 10.1021/es405079b

Xie, H., Huang, S. Martin, S. and Wise, Sr., J.P. Arsenic is Cytotoxic and Genotoxic to Primary Human Lung Cells. Mutation Research 760:  33-41, 2014.

Savery, L.C., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., and Wise, Sr., J.P. Global Assessment of Oceanic Lead Pollution using Sperm Whales (Physeter macrocephalus) as an Indicator Species. Marine Pollution Bulletin 79(1-2): 236–244, 2014.

Martino, J. Wise, S.S., Perkins, C., Sironi, M. and Wise, Sr., J.P. Metal Levels in Southern Right Whales (Eubalaena australis) from Península Valdés, Argentina. Journal of Environmental and Analytical Toxicology 3(6):  190-195, 2013. doi: 10.4172/2161-0525.1000190

Holmes, A.L., The, T., Thompson, K., Mason, M., Kandpal, S., Zheng, T., and Wise, Sr., J.P. Chronic Exposure to Particulate Nickel Induces Neoplastic Transformation in Human Lung Epithelial Cells. Toxics 1(1): 46-59, 2013. doi:10.3390/toxics1010046

Wise, Sr., J.P. and Qin, Q. Hexavalent Chromium and DNA, Biological Implications of Interaction. In: Kretsinger, R.H., Uversky, V.N. and Permyakov, E.A. (Eds.). Encyclopedia of Metalloproteins. 1st ed. Springer, New York. Pages 975-977.2013. DOI 10.1007/978-1-4614-1533-6. ISBN 978-1-4614-1532-9

Savery, L.C., Evers, D., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Kerr, I., Payne, R. Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., Benedict, L. and Wise, Sr., J.P. Global Mercury and Selenium Concentrations in Skin from Free-Ranging Sperm Whales (Physeter macrocephalus). Science of the Total Environment 450–451: 59–71, 2013.

Pabuwal, V., Boswell, M., Pasquali, A., Wise, S.S., Kumar, S., Shen, Y., Garcia, T., LaCerte, C., Wise, Jr., J.P., Wise, Sr., J.P., Warren, W. and Walter, R.B. Transcriptomic Analysis of Cultured Whale Skin Cells Exposed to Hexavalent Chromium [Cr(VI)]. Aquatic Toxicology 134-135: 74-81, 2013.

Savery, L.C., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Thompson, W.D., Perkins, C., Mason, M.D., Payne, R. Kerr, I. and Wise, Sr., J.P. A Global Assessment of Silver Pollution using Sperm Whales (Physeter macrocephalus) as an Indicator Species. Journal of Environmental and Analytical Toxicology 3 (2):169-177, 2013. http://dx.doi.org/10.4172/2161-0525.1000169.

Karri, N.P., Xie, H. and Wise, Sr., J.P. Chronic Exposure to Particulate Hexavalent Chromium Alters Cdc20 Protein Localization, Interactions and Expression. Journal of Carcinogenesis & Mutagenesis 4(2): 140-147, 2013. http://dx.doi.org/10.4172/2157-2518.1000140.

Wise, Sr., J.P. and Qin, Q. Biological implications of the interaction Springer, Berlin Heidelberg New York. 2013

Wise, C.F., Wise, Jr., J.P., Wise, S.S., and Wise, Sr., J.P. Skin Biopsy Applications in Free Ranging Marine Mammals: A Case Study of Whale Skin Biopsies as a Valuable and Essential Tool for Studying Marine Mammal Toxicology and Conservation. Chapter 5, pp. 109-122 in Romero, A. and Keith, E.O. (eds.) New Approaches to the Study of Marine Mammals. InTech, Rijeka, Croatia. 2012.

Holmes, A.L. and Wise, Sr., J.P. Aneuploidy: Mechanisms, Cancer and the Role of Environmental Pollutants. Chapter 1, pp. 1-33 in de Rossi, S. and Bianchi, F. (eds.) Aneuploidy: Etiology, Disorders and Risk Factors. Nova Science Publishers Inc., Hauppauge, NY. 2012.

Kost, G.C., Patierno, S.R., , Wise, S.S., Holmes, A.L., Wise, Sr., J.P. and Ceryak, S. Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: Decreased CIN at the expense of enhanced GIN? Mutation Research 735: 51– 55, 2012.

Wise, S.S. and Wise, Sr., J.P. Chromium and Genomic Stability. Mutation Research, 733: 78– 82, 2012. (PMID: 22192535)

Wise, J.P. Hexavalent Chromium Compounds. In: Schwab M. (ed). Encyclopedia of Cancer, 2nd ed. Springer, Berlin Heidelberg New York. 2012.

LaCerte, C. and Wise, Sr., J.P. The Potential Threat of Genotoxic Metals to Marine Mammal Health: A Case Study of Chromium Toxicity in Toothed and Baleen Whales in  Aquatic Animals, Biology, Habitats, and Threats. Chapter 3, pp 77-97, in Eder D.L. (ed.) Aquatic Animals: Biology, Habitats and Threats. Nova Science Publishers Inc., Hauppauge, NY. 2012.

Li Chen, T., LaCerte, C., Wise, S.S., Holmes, A., Martino, J., Wise, Jr., J.P., Thompson, W.D. and Wise, Sr., J.P. Comparative Cytotoxicity and Genotoxicity of Particulate and Soluble Hexavalent Chromium in Human and Sperm Whale (Physeter macrocephalus) Skin Cells. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 155: 143–150, 2012. (PMID: 21466859)

Wise, J. and Wise, Sr., J.P. A Review of the Toxicity of Chemical Dispersants. Reviews on Environmental Health 26(4): 281-300, 2011.

Xie, H. and Wise, Sr., J.P. Genotoxicity of Metal Nanoparticles. Reviews on Environmental Health 26(4): 251-268, 2011.

Ali, A., Ma, Y., Reynolds, J., Wise, Sr., J.P., Inzucchi, S.E. and Katz, D.L. Chromium Effects on Glucose Tolerance, Insulin Sensitivity and Vascular Function in People at Risk for Diabetes. Endocrine Practice 17(1):16-25, 2011.

Wise, S.S. and Wise, Sr., J.P. Letter to the Editor. Toxicology 285: 81–82, 2011.

Wise, Sr., J.P., Thompson, W.D., Wise, S.S., LaCerte, C., Wise, J., Gianios, Jr., C., Perkins, C., Zheng, T., Benedict, L., Mason, M., Payne, R. and Kerr, I. A Global Assessment of Gold, Titanium, Strontium and Barium Pollution using Sperm Whales (Physeter macrocephalus) as an Indicator Species. Journal of Ecosystem and Ecography 1(1):1-9, 2011. doi:10.4172/2157-7625.1000101.

Markowski, V.P., Currie, D., Reeve, E.A., Thompson, W.D. and Wise, Sr., J.P. Tissue-Specific and Dose-Related Accumulation of Arsenic in Mouse Offspring Following Maternal Consumption of Arsenic-Contaminated Water. Basic & Clinical Pharmacology & Toxicology 108: 326-332, 2011.

Wise, Sr., J.P., Wise, S.S., LaCerte, C., Wise, Jr., J.P., and Aboueissa, A. The Genotoxicity of Particulate and Soluble Chromate in Sperm Whale (Physeter macrocephalus) Skin Fibroblasts. Environmental and Molecular Mutagenesis, 52: 43-49, 2011. (PMID: 20839228) 

2006-2010

Wise, S.S., and Wise, Sr., J.P. Aneuploidy as an Early Mechanistic Event in Metal Carcinogenesis. Biochemical Society Transactions 38(6): 1650-1654, 2010. 

Holmes, A.L. and Wise, Sr., J.P. Mechanisms of Metal-Induced Centrosome Amplification. Biochemical Society Transactions 38(6): 1687-1690, 2010.

Wise, Sr., J.P., Wise, S.S., Holmes, A.L., LaCerte, C., Shaffiey, F, and Aboueissa, A. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Steller Sea Lion Lung Fibroblasts Compared to Human Lung Fibroblasts. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology 152(1): 91-98, 2010.

Wise Jr., J.P., Wise, S.S., Wise, J., McKay, J., Browne, M., Joyce, K., Braun, M., Wise, C., Duffy, R., Estell, E., Brown, J., Gianios Jr., C., Mason, M., Shehata, T., Hammond, D., Thompson, W.D., and Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity. Gravitational and Space Biology, 23(2): 83-84, 2010.

Wise, Sr., J.P., Goodale, B.C., Wise, S.S., Craig, G., Pongan A.F., Walter, R.B., Thompson, W.D., Ng, A.K., Aboueissa, A.M., Mitani, H., Spalding, M.J. and Mason, M.D. Silver Nanospheres Are Cytotoxic and Genotoxic to Fish Cells. Aquatic Toxicology, 97: 34–41, 2010. (PMID: 20060603)

LaCerte, C., Xie, H., Abouiessa, A. and Wise, Sr., J.P. Particulate Depleted Uranium Is Cytotoxic and Clastogenic to Human Lung Epithelial Cells.Mutation Research, 697: 33–37, 2010.

Holmes, A.L., Wise, S.S., Pelsue, S.C., Aboueissa, A., Lingle, W., Salisbury, J., Gallagher, J. and Wise, Sr., J.P. Chronic Exposure to Zinc Chromate Induces Centrosome Amplification and Spindle Assembly Checkpoint Bypass in Human Lung Fibroblasts. Chemical Research in Toxicology, 23(2): 386-395, 2010 (PMID: 20030412).

Xie, H., LaCerte, C., Thompson, W.D. and Wise, Sr., J.P. Depleted Uranium Induces Neoplastic Transformation in Human Lung Epithelial Cells. Chemical Research in Toxicology. 23(2): 373-378, 2010.

Wise, S.S., Holmes, A.L., Qin, Q., Xie, H., Katsifis, S., Thompson, W.D. and Wise, Sr., J.P. Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in Human Bronchial Cells. Chemical Research in Toxicology. 23(2): 365-372, 2010.

Jones, B.A., Christensen, A., Wise, Sr., J.P., Yu, H. Glutathione S-Transferase Polymorphisms and Survival from Colorectal Cancer. Cancer Epidemiology. 33(3-4): 249-256, 2009.

Li Chen, T., Wise, S.S., Holmes, A., Shaffiey, F., Wise, Jr., J.P., Thompson, W.D., Kraus, S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Hexavalent Chromium in Human and North Atlantic Right Whale (Eubalaena glacialis) Lung Cells. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 150(4): 487-494, 2009. (PMID: 19632355)

Alley, D. F., Gordon, N. R., Langley-Turnbaugh, S., Wise, Sr., J.P., Van Epps, G. and Jalbert, A. The Effect of PM10 on Human Lung Fibroblasts. Toxicology and Industrial Health. 25: 111–120, 2009.

Li Chen, T., Wise, S.S., Kraus, S., Shaffiey, F., Grau, M., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., O’Hara, T. and Wise, Sr., J.P. Particulate Hexavalent Chromium Is Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis) Lung and Skin Fibroblasts. Environmental and Molecular Mutagenesis. 50(5): 387-393, 2009. (PMID: 19230002)

Wise, Sr., J.P., Payne, R., Wise, S.S., LaCerte, C., Wise, J., Gianios, Jr., C., Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., Benedict, L. and Kerr, I. A Global Assessment of Chromium Pollution using Sperm Whales (Physeter macrocephalus) as an Indicator Species. Chemosphere.75: 1461–1467, 2009.

Wise, S.S., Shaffiey, F, LaCerte, C., Goertz, C,E.C., Dunn, J.L., Gulland, F.M.D., Thompson, W.D., Aboueissa, A., and Wise, Sr., J.P. Particulate and Soluble Hexavalent Chromium Are Cytotoxic and Genotoxic to Steller Sea Lion Lung Cells. Aquatic Toxicology. 329-335, 2009.

Wise, J. Hexavalent Chromium Compounds. In: Schwab M. (ed). Encyclopedia of Cancer, 2nd edn. Springer, Berlin Heidelberg New York. 2009.

Ierardia, J.L., Manciab, A., McMillan, J., Lundqvist, M.L., Romano, T.A., Wise, Sr., J.P., Plant, A. and Warr, G.W. Sampling the Skin Transcriptome of the North Atlantic Right Whale. Comparative Biochemistry and Physiology.4: 154–158, 2009.

Xie, H., Holmes, A.L., Young, J.L., Qin, Q., Joyce, K, Pelsue, S.C., Peng, C., Wise, S.S., Jeevarajan, A., Wallace, W.T., Hammond, D., and Wise, Sr., J.P. Zinc Chromate Induces Chromosome Instability and DNA Double Strand Breaks in Human Lung Cells. Toxicology and Applied Pharmacology. 234: 293–299, 2009.

Wise, Sr., J.P., Wise, S.S., Goodale, B.C., Shaffiey, F., Kraus, S., and Walter, R.B. Medaka (Oryzias latipes) as a Sentinel Species for Aquatic Animals: Medaka Cells Exhibit a Similar Genotoxic Response as North Atlantic Right Whale Cells. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 149: 210–214, 2009.

Holmes, A.L., Wise, S.S., Goertz, C.E.C., Dunn, J.L., Gulland, F.M.D., Gelatt, T., Beckmen, K.B., Burek, K., Atkinson, S., Bozza, M., Taylor, R., Zheng, T., Zhang, Y., Aboueissa , A., and Wise, Sr., J.P. Metal Tissue Levels in Steller Sea Lion (Eumetopias jubatus) Pups. Marine Pollution Bulletin 56(8) 1416-1421, 2008.

Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Hexavalent chromium-induced DNA damage and repair mechanisms. Reviews on Environmental Health 23(1): 39-57, 2008.

Brooks, B., O’Brien, T.J., Ceryak, S., Wise, Sr., J.P., Wise, S.S., Wise, Jr., J.P., DeFabo, E. and Patierno, S.R. Excision Repair is Required for Genotoxin-Induced Mutagenesis in Mammalian Cells. Carcinogenesis. 29(5): 1064–1069, 2008.

Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani, H., Wise Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Medaka (Oryzias latipes) Cells. Aquatic Toxicology 87: 60–67, 2008.

Wise, Sr. J.P., Wise, S.S, Kraus, S. Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., and O’Hara, T. Hexavalent Chromium Is Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis) Lung and Testes Fibroblasts. Mutation Research. 650: 30–38, 2008.

Xie, H., Wise, S.S., and Wise, Sr., J.P. Deficient Repair of Particulate Chromate-Induced DNA Double Strand Breaks Leads To Neoplastic Transformation. Mutation Research. 649: 230-238, 2008.

Xie, H., Holmes, A.L., Wise, S.S., Huang, S., Peng, C., and Wise, Sr., J.P. Neoplastic Transformation of Human Bronchial Cells by Lead Chromate Particles. American Journal of Respiratory Cell and Molecular Biology. 37(5): 544-552, 2007.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C., Thompson, W.D., Thacker, J., Thompson, L.H., Hinz, J.M., and Wise, Sr., J.P. Homologous Recombination Protects Against Particulate Chromate-Induced Genomic Instability in Chinese Hamster Cells. Mutation Research. 625: 145-154, 2007.

Zhang, Y., Holford, T.R., Leaderer, B.,Boyle, B., Zhu, Y., Wang, R., Zou, K., Zhang, B., Wise, Sr., J.P., Qin, Q., Kilfoy, B., Han, J., and Zheng, T. Ultraviolet Radiation Exposure and Risk of Non-Hodgkin Lymphoma. American Journal of Epidemiology, 165(11):1255-64, 2007.

Wise, S.S., Thompson, W.D., Aboueissa, A., Mason, M.D., and Wise, Sr., J.P. Particulate Depleted Uranium Is Cytotoxic and Clastogenic to Human Lung Cells. Chemical Research in Toxicology, 20(5):815-820, 2007.

Camrye, E., Wise, S.S., Milligan, P., Gordon, N., Goodale, B., Stackpole, M., Patzlaff, N.,  Aboueissa, A., and Wise, Sr., J.P. Ku80 Deficiency Does Not Affect Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological Sciences, 97(2):348 -54, 2007.

Savery, L.C., Grlickova-Duzevik, E., Wise, S.S., Thompson, W.D., Hinz, J.M., Thompson, L.H., and Wise, Sr., J.P. Role of the Fancg Gene in Protecting Cells from Particulate Chromate-Induced Chromosome Instability. Mutation Research, 626(1-2): 120-127, 2007.

Wise, Sr., J.P. Genotoxic and Carcinogenic Effects of Lead. In, U.S. EPA. Air Quality Criteria for Lead (Final). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-05/144aF-bF, 5-125 – 5-147, 2006.

Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., and Wise, Sr., J.P. Chronic Exposure to Particulate Chromate Induces Spindle Assembly Checkpoint Bypass in Human Lung Cells. Chemical Research in Toxicology, 19(11):1492-1498, 2006.

Grlickova-Duzevik, E., Wise, S.S., Munroe, R.C., Thompson, W.D., and Wise, J.P., Sr. XRCC1 Protects Cells from Chromate-Induced Chromosome Damage, but Does Not Affect Cytotoxicity. Mutation Research, 610(1-2): 610:31-37, 2006.

Holmes, A.L., Wise, S. S., Sandwick, S.J., and Wise, Sr., J.P. The Clastogenic Effects of Chronic Exposure to Particulate and Soluble Cr (VI) in Human Lung Cells. Mutation Research, 610(1-2): 8-13, 2006.

Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Particulate and Soluble Hexavalent Chromium Are Cytotoxic and Genotoxic to Human Lung Epithelial Cells. Mutation Research, 610(1-2): 2-7, 2006.

Duzevik, E.G., Wise, S.S., Munroe, R.C., Thompson, W.D., and Wise, Sr., J.P. XRCC1 Protects against Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological Sciences 92(2):409-415, 2006.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T., and Wise, Sr., J.P. Benzo[a]pyrene Cytotoxicity in Right Whale (Eubalaena glacialis) Skin, Testis and Lung Cell Lines. Marine Environmental Research 62:S20-S24, 2006.

Wise, Sr., J.P., Goertz, C.E.C., Wise, S.S., Morin, A.T., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson, S., and Thompson, W.D. Chromium Cytotoxicity in Steller Sea Lion Lung, Skin and Testes Cells. In Trites, A.W., Atkinson, S.K., DeMaster, D.P., Fritz, L.W., Gelatt, T.S., Rea, L.D., and Wynne, K.M. (Eds), Sea Lions of the World Conservation and Research in the 21st Century. Alaska Sea Grant College Program, pp. 57-68, 2006.

Holmes, A.L., Wise, S. S., Sandwick, S.J., Lingle, W.L., Negron, V.C., Thompson W.D., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in Human Lung Cells. Cancer Research 66(8):4041-4048, 2006.

Grlickova-Duzevik E., Wise, S.S., Munroe, R.C., Thompson, W.D., and Wise, J.P., Sr. XRCC1 Protects Against Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological Sciences, 92(1): 96-102, 2006

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2001-2005

Wise, Sr., J.P. Lobster Shell Disease Workshop. Environmental contaminants: A Potential Confounding Factor to Lobster Shell Disease in the American Lobster (Homarus americanus) Aquatic Forum Series 05-1. Tlusty, M.F., Halvorson, H.O., Smolowitz, R., and Sharma, U. (eds.) New England Aquarium, Boston Massachusetts. 2005.

Wise, S.S., Holmes, A.L., Moreland, J.A., Xie, H., Sandwick, S.J., Stackpole, M.M., Fomchenko, E., Teufack, S., May, Jr., A.J., Katsifis, S.P., and Wise, Sr., J.P. Human Lung Cell Growth Is Not Stimulated by Lead Ions after Lead Chromate-Induced Genotoxicity. Molecular and Cellular Biochemistry 279 (1-2):75-84, 2005.

Xie, H., Wise, S. S., Holmes, A.L., Xu, B., Wakeman, T., Pelsue, S.C., Singh, N.P., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks in Human Lung Cells. Mutation Research 586(2):160-172, 2005.

Holmes, A.L., Wise, S. S., Xie, H., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Lead Ions Do Not Cause Human Lung Cells to Escape Chromate-Induced Cytotoxicity. Toxicology and Applied Pharmacology 203:167–176, 2005.

O’Hara, T., P. Hoekstra, C. Rosa, L. Dehn, D. Muir, V. Woshner, J. Wise, G. Ylitalo, D. Wetzel, G. Bratton. Bowhead Whale Contaminants: A Review of Current State of Knowledge and Possible Future Research Directions. SC/56/E1 at the International Whaling Commission Scientific Committee: 29 June to 10 July, Sorrento, Italy, p. 16, 2004.

Xie, H., Holmes, A.L., Wise, S. S., Gordon, N., and Wise, Sr., J.P. Lead Chromate-Induced Chromosome Damage Requires Extracellular Dissolution to Liberate Chromium Ions but Does Not Require Particle Internalization or Intracellular Dissolution. Chemical Research in Toxicology 17 (10):1362-1367, 2004.

Zhang, Y, Wise, Sr., J.P., Holford, T.R., Xie, H., Boyle, P., Zahm, S.H., Zou, K.Y., Zhang B., Owens, P.H., and Zheng, T. Serum Polychlorinated Biphenyls, Cytochrome P4501A1 Polymorphisms, and Risk of Breast Cancer in Connecticut Women. American Journal of Epidemiology 160(12):1177- 1183, 2004.

Wise, S.S., Schuler, J.H.C., Holmes, A.L., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Zheng T., and Wise, Sr., J.P. A Comparison of Two Carcinogenic Particulate Hexavalent Chromium Compounds: Barium Chromate Is More Genotoxic than Lead Chromate in Human Lung Cells. Environmental and Molecular Mutagenesis 44:156-162, 2004.

Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., Thompson, W.D., and Wise, Sr., J.P. Chromium Is the Proximate Clastogenic Species for Lead Chromate-Induced Clastogenicity in Human Bronchial Cells. Mutation Research 560:79-89, 2004.

Wise, S.S., Schuler, J.H.C., Katsifis, S.P., and Wise, Sr., J.P. Barium Chromate Is Cytotoxic and Genotoxic to Human Lung Cells. Environmental and Molecular Mutagenesis 42:274-278, 2004.

Wise, S.S., Elmore, L.W., Holt, S.E., Little, J.E., Antonucci, P.G., Bryant, B.H., and Wise, Sr., J.P. Telomerase-Mediated Lifespan Extension of Human Bronchial Cells Does Not Affect Hexavalent Chromium-Induced Cytotoxicity or Genotoxicity. Molecular and Cellular Biochemistry 255:103-111, 2004.

Zheng, T., Boyle, P., Zhang, B., Zhang, Y., Owens, P.H., Lan, Q., and Wise, J. Tobacco Use and Risk of Oral Cancer . In: Boyle P, ed. Tobacco: The Public Health Disaster of the 20th Century. Oxford University Press, Oxford, UK., 2003

Zheng, T., Holford, T.R., Zahm, S.H., Owens, P.H., Boyle, P., Zhang, Y., Wise, Sr., J.P., and Ali-Osman, F. Glutathione S-transferase M1 and T1 Genetic Polymorphisms, Alcohol Consumption and Breast Cancer Risk. British Journal of Cancer 88:58-62, 2003.

Zheng, T., Holford, T.R., Zahm, S.H., Owens, P.H., Boyle, P., Zhang, Y., Wise, Sr., J.P., Stephenson, L.P., and Ali-Osman, F. Cigarette Smoking, Glutathione S-Transferase M1 and T1 Genetic Polymorphisms, and Breast Cancer Risk (United States). Cancer Causes Control 13:637-645, 2002.

Rabinowitz, P.M., Wise, Sr., J.P., Antonucci, P.G., and Mobo, B.H. Glutathione-S-Transferase Polymorphism and High Frequency Otoacoustic Emissions in Noise-Exposed Workers. Hearing Research 173:164-171, 2002.

Wise, Sr., J.P., Wise, S.S., and Little, J.E. The Cytotoxicity and Genotoxicity of Particulate and Soluble Hexavalent Chromium in Human Lung Cells. Mutation Research 517:221-229, 2002.

Wise, Sr., J.P., Winn, R.N., and Renfro, J.L. Generating New Marine Cell Lines and Transgenic Species. Journal of Experimental Zoology 292:271-220, 2002.

Wise, J., and Lechner, J.F. Normal Human Bronchial Epithelial Cell Culture. Chapter 8 in Freshney, R.I. and Freshney, M.G. (eds.) Culture of Epithelial Cells: A Manual of Technique. Wiley Inc, New York, NY. 2001.

1996-2000

Borak J., and Wise, Sr., J.P. Does Aluminum Exposure of Pregnant Animals Lead to Accumulation in Mothers or Their Offspring? Teratology 57:127-139, 1998.

Borak J., and Wise, J.P. DNA-Protein Crosslinks as Biomarkers of Formaldehyde Exposure. International Journal of Occupational and Environmental Health 3(4):307, 1997.

Wise, Sr., J.P., and Stearns, D.M. Chromium carcinogenicity: The Roles of Valence State and Solubility. Occupation and Environmental Medicine Report 11(11):100-103, 1997.

Blankenship, J.J., Carlisle, D., Wise, Sr., J.P., Orenstein, J.M., Dye, L.E., and Patierno, S.R. Induction of Apoptotic Cell Death by Particulate Lead Chromate: Differential Effects of Vitamins C and E on Genotoxicity and Survival. Toxicology and Applied Pharmacology 146:270-280, 1997.

Stearns, D.M., Wise, Sr., J.P., Patierno, S.R., and Wetterhahn, K.E. Chromium (III) Picolinate Produces Chromosome Damage in Chinese Hamster Ovary Cells. The FASEB Journal 9:1643-1648, 1995.

1991-1995

Patierno, S.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C., and Manning, F.C.R. Genotoxin-Induced Apoptosis: Implications for Carcinogenesis. In: Hu, V.W. (Ed), The Cell Cycle: Regulators, Targets and Clinical Applications. Plenum Press, pp. 331-340, 1994.

Manning, F.C.R., Blankenship, L., Wise, J.P., Xu, J., Bridgewater, L.C., and Patierno, S.R. Induction of Internucleosomal Fragmentation by Carcinogenic Chromate: Relationship to Genotoxicity, Cell Cycle Delay, and Inhibition of Macromolecular Synthesis. Environmental Health Perspectives 102:159 -167, 1994.

Wise, Sr., J.P., Stearns, D.M., Wetterhahn, K.E., and Patierno, S.R. Cell-Enhanced Dissolution of Carcinogenic Lead Chromate Particles: The Role of Individual Dissolution Products in Clastogenesis. Carcinogenesis 15:2249-2254, 1994.

Clawson, G.A., Norbeck, L.L., Wise, J.P., and Patierno, S.R. An Inhibitor of Nuclear Scaffold Protease Blocks Chemically Induced Transformation of Embryonic Fibroblasts. Cell Growth and Differentiation 4:589-594, 1993.

Wise, J.P., Orenstein, J.M., and Patierno, S.R. Inhibition of Lead Chromate Clastogenesis by Ascorbate: Relationship to Particle Dissolution and Uptake. Carcinogenesis 14:429-434, 1993.

Xu, J., Wise, J.P., and Patierno, S.R. DNA Damage Induced by Carcinogenic Lead Chromate Particles in Cultured Mammalian Cells. Mutation Research 280:129-136, 1992.

Wise, J.P., Leonard, J.C., and Patierno, S.R. Clastogenicity of Lead Chromate Particles in Hamster and Human Cells. Mutation Research 278:69-79, 1992.

Published Abstracts (return to top)

(1991-1995 | 1996-2000 | 2001-2005 | 2006-2010 | 2011-2015)

2011-2015

Savery, L.C., Wise, J.T.F., Wise, S.S., Falank, C., Gianios, Jr., C., Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., and Wise, Sr., J.P. Global Assessment of Arsenic Pollution Using Sperm Whales (Physeter macrocephalus) As an Indicator Species. Toxicological Sciences, 138: 1303, 2014.

Wise, S.S., Xie, H., Wise, Jr., J.P., Wise, C.F., Guillette, Jr., L.J., and Wise, Sr., J.P. Comparative Toxicity of Hexavalent Chromium (Cr(VI)) in Human and Alligator Cells. Toxicological Sciences, 138: 1279, 2014.

Stewart J., Nutter N., Wise, Sr., J.P. and Xie H. Synergistic Effect of Arsenic on Hexavalent Chromium Cytotoxicity and Genotoxicity in Human Lung Cells. Toxicological Sciences, 138: 1320, 2014.

Xie, H., Şekeroğlu V., Şekeroğlu Z., Falank C., Holmes A. L. and Wise, Sr., J.P. Depleted Uranium Induces DNA Damage and Alteration of DNA Repair Proteins in Human Lung Epithelial Cells. Toxicological Sciences, 138: 1942, 2014.

Browning, C.L., Xie, H., Qin, Q., Masson, J.Y., and Wise, Sr., J.P. Prolonged Exposure to Particulate Chromate Inhibits Homologous Recombination Repair Proteins. Toxicological Sciences, 138: 1924, 2014.

Holmes, A., Smith, L.J., Wise, S.S., Mason, M., Zheng, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Soluble and Particulate Cobalt in Human Lung Fibroblasts. Toxicological Sciences, 138: 1276, 2014.

Wise, C.F., Wise, J., Wise, S.S., and Wise, Sr., J.P. Toxicity of Chemical Dispersants, Oil and Chemically Dispersed Oil in Sperm Whale Skin Cells. Toxicological Sciences, 138: 448, 2014.

Martino, J., Holmes, A.L., Xie, H., Nigg, E. and Wise, Sr., J.P. Particulate Hexavalent Chromium Causes Centrosome Separation by Activating the Kinase Nek2A. Toxicological Sciences, 138; 1272, 2014.

Wise, Sr., J.P., Qin, Q., Browning, C., Wise, S.S., Xie, H., and Holmes, A.L. Prolonged Exposure to Particulate Chromate Induces a Switch from Homologous Recombination Repair to Non-Homologous End Joining Repair in Human Lung Cells. Toxicological Sciences, 138: 1450, 2014.

Wise, C.F., Wise, J.T.F., Wise, S.S., Wise, Sr., J.P. The Cytotoxic and Genotoxic Impacts of Chemical Dispersants, Oil and Chemically Dispersed Oil on Sperm Whale Skin Cells. Proceedings of the Gulf of Mexico Oil Spill and Ecosystem Science Conference, p.50, 2014.

Şekeroğlu, V., Xie, H., Holmes, A.L., and Wise, Sr., J.P. Depleted Uranium Induces DNA Double Strand Breaks and Cell Death in Human Lung Epithelial Cells. Proceedings of the 1st International Cell Death Research Congress, page 124.

Şekeroğlu, Z.A., Holmes, A.L. and Wise, Sr., J.P. Exposure to Particulate Chromate Induces Cytotoxicity and Chromosome Instability in Human Bladder Cells. Proceedings of the 1st International Cell Death Research Congress, page 117.

Wise, S.S., Holmes, A.L., Xie, H., Martino, J., Raph, S., Thompson, W.D. and Wise, Sr., J.P. Chromosome Instability Induced by Hexavalent Chromium is a Result of Impaired DNA Repair and Mitotic Disruption. Journal of Clincal Toxicology 3: 36, 2013.

Wise, Sr., J.P., Xie, H., Holmes, A.L., Falank, C., Karri, N.D. and Wise, S.S. Particulate Chromate Alters the Localization of Proteins that Protect Cells against Chromosome Instability. Journal of Clincal Toxicology 3: 35, 2013.

Wise, S.S., Holmes, A.L., Xie, H., Martino, J., Raph, S., Thompson, W.D. and Wise, Sr., J.P. Hexavalent Chromium Impairs DNA Repair Resulting in Mitotic Disruption and Chromosome Instability. Environmental and Molecular Mutagenesis 52: P21, 2013.

Hernandez-Ramon, E.E., Wise, Sr., J.P., Si, N., Wise, S.S., Wise, Jr., J.P. and Poirier, M.C. Detection of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in epidermis from sperm whales (Physeter macrocephalus) in the Gulf of Mexico. Environmental and Molecular Mutagenesis 52: P87, 2013.

The, T., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure to Particulate Nickel Induces Neoplastic Transformation in Human Lung Epithelial Cells. Environmental and Molecular Mutagenesis 52: P41, 2013.

Wise, C.F., Wise, S.S., Wise, Sr., J.P. Toxicity of chemical dispersants, oil and chemically dispersed oil in sperm whale skin cells (Physeter macrocephalus). Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 44: 143, 2013.

Wise, Jr., J.P., Wise, J.T.F., Thompson, W.D., Perkins, C. and Wise, Sr., J.P. Is Genotoxic Metal Exposure Part of The Toxic Legacy Of The Deepwater Horizon Oil Crisis? Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 44: 147, 2013.

Martino, J., Holmes, A.L. and Wise, Sr., J.P. Investigating the Effects of Particulate Hexavalent Chromium on the Centrosome Cycle in Human Lung Cells. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Raph, S., Xie, H. and Wise, Sr., J.P. Hexavalent Chromium Exposure Decreases Mad1 and Mad2 Localization and Interaction in Human Lung Fibroblasts. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Smith, L.J., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure of Cobalt Induces Cytotoxicity and Genotoxicity in Human Lung Cells. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Thompson, K., Wise, S.S. and Wise, Sr., J.P. Investigating if Large Whale Species and Humans have differential rates of DNA Double Strand Break Repair. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Stewart, J., Xie, H. and Wise, Sr., J.P. Arsenic and Hexavalent Chromium Co-treatment Toxicity in Human Lung Cells. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Wise, J., Wise, S.S., Xie, H., Griffitt, J. and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic to Human Lung and Skin Fibroblasts. Toxicological Sciences, 132: 32, 2013. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Falank, C. and Wise, Sr., J.P. Chronic Exposure to Particulate Hexavalent Chromium Disrupts Shugoshin1 Localization in Human Lung Cells. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Braun, M., Sacco, J., Lechner, J. and Wise, Sr., J.P. E162 Protects Against Chromium (VI)-Induced Cytotoxicity and Genotoxicity in Human Lung Fibroblast Cells. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Smith, A., Martino, J., Wise, S.S., Holmes, A.L. and Wise, Sr., J.P. Lead Chromate Induces Persistent Centrosome Amplification in Human Lung Cells. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Keim, E., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Nickel Compounds Are Cytotoxic and Genotoxic to Sperm Whale Skin Fibroblasts. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Sassman, M.L., Wise, S.S. and Wise, Sr., J.P.  A Comparison of DNA Double Strand Break Repair between Sperm Whales Individuals and Humans. Proceedings of the University of Southern Maine’s 10th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2013.

Savery, L.C., Holmes, A.L., Braun M.C., Evers, D.C., Kerr I., Payne R., Thompson W.D., Perkins, C., Zheng, T., Zhu, C., and Wise, Sr., J.P. Selenium Protects Against the Toxic Effects of Methylmercury in Sperm Whale (Physeter macrocephalus) Skin Cells. Toxicological Sciences, 132: 328, 2013.

Qin, Q., Xie, H., Holmes, A.L., Wise, S.S., and Wise, Sr., J.P. Chronic Exposure to Particulate Chromate Induces Persistent DNA Double Strand Breaks in Human Lung Cells. Toxicological Sciences, 132: 250, 2013.

Wise, C., Wise, S.S., Holmes, A., and Wise, Sr., J.P. Fin Whale Cells Are More Resistant to Particulate Chromate Cytotoxicity than Human Cells. Toxicological Sciences, 132: 251, 2013.

Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., and Wise, Sr., J.P. Repeated particulate chromate exposure induces chromosome instability, a DNA double strand break repair-deficient phenotype, and neoplastic transformation in human lung cells. Toxicological Sciences, 132: 250, 2013.

Wise, Jr., J.P., Wise, J., Thompson, W.D., Perkins, C., and Wise, Sr., J.P. Is Genotoxic Metal Exposure Part of the Toxic Legacy of the Deepwater Horizon Oil Crisis? Toxicological Sciences, 132: 330, 2013.

Falank, Carolyne, and Wise, Sr., J.P. Chronic exposure to particulate hexavalent chromium disrupts shugoshin1 localization in human lung cells. Toxicological Sciences, 132: 123, 2013.

Wise, J., Wise, S.S., Xie, H., Griffitt, J., and Wise, Sr., J.P. Chemical Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic to Human Lung and Skin Fibroblasts. Toxicological Sciences, 132: 32, 2013.

Holmes, A.L., Hebert, M., Case, C.P., and Wise, Sr., J.P. Development of an Immortalized Urothelial Cell Line to Study Metal-Induced Bladder Carcinogenesis. Toxicological Sciences, 132: 254, 2013.

Braun, M., Sacco, J., Lechner, J., and Wise, Sr., J.P. E162 Protects Against Chromium (VI)-Induced Cytotoxicity and Genotoxicity in Human Lung Fibroblast Cells. Toxicological Sciences, 132: 250, 2013.

Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., and Wise, Sr., J.P. Repeated Particulate Chromate Exposure Induces a Permanent Phenotypic Change of Genomic Instability, DNA Double Strand Break Repair Deficiency and Neoplastic Transformation in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and DNA Repair, p 201, 2013.

Qin, Q., Wise, S.S., Xie, H., Holmes, A.L., and Wise, Sr., J.P. Chronic Particulate Chromate Exposure Induces Persistent DNA Double Strand Breaks and Suppresses Rad51 Response in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and DNA Repair, p 201, 2013.

Wise, Sr., J.P., Kerr, I, Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wise, J., Gianios, Jr., C., Wallace, B., Huang, S., LaCerte, C. and Holmes, A.L. Voyage 2 of the Odyssey: The Impact of the Oil Crisis on Health Using Whales As An Indicator Species. Proceedings of the anual meeting of the American Association for the Advancement of Science (AAAS), p 73, 2013.

Kerr, I and Wise, Sr., J.P. The DeepWater Horizon Disaster. Proceedings of the anual meeting of the American Association for the Advancement of Science (AAAS), p 73, 2013.

Wise, Sr., J.P. and Griffitt, J. The Toxicological Impact of Metals, Crude Oil, and Chemical Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health. Proceedings of the anual meeting of the American Association for the Advancement of Science (AAAS), p 72, 2013.

Wise, Sr., J.P., Wise, Jr., J.P., Wise, J., Perkins, C., and Thompson, W.D. Is Exposure to Genotoxic Metals Part of the Toxic Legacy of the Deepwater Horizon Oil Crisis? Proceedings of the Gulf of Mexico Oil Spill and Ecosystem Science Conference, p.30, 2013.

Falank, Jr., L.F., Wise, C.F., and Wise, Sr, J.P. Chemical Dispersants Are Cytotoxic to Humpback Whale and Sperm Whale Skin Cells. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 401, 2012.

Wise, J., Wise, S.S., Xie, H., Griffitt, J., and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico Oil Crisis Response Are Cytotoxic to Human Skin Fibroblasts. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 200, 2012.

Wise, Jr., J.P., Wise, C., Keim, E., Wise, Sr., J.P. Comparison of Observed Nickel Levels and Nickel Toxicity in Whales. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 401, 2012.

Wise, C.F., Wise, S.S., and Wise, Sr., J.P. Chemical Dispersants Used in The Gulf of Mexico Are Cytotoxic to Sperm Whale Skin Fibroblasts. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 401, 2012.

Braun, M., Sacco, J., Falank, L. and Wise, Sr., J.P. Nutraceuticals Protect Against Chromium(VI)-Induced Cytotoxicity and Genotoxicity in Human Lung Fibroblast Cells. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Browning, C.L., Holmes, A.L., Mason, M., Kandpal, S. and Wise, Sr., J.P. Assessing the Toxicity of an Emerging Environmental Pollutant: Titanium Dioxide Nanoparticles. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Duffy, R., Holmes, A. and Wise, Sr., J.P. Elucidating the Role of Nek2A in Zinc Chromate-Induced Centrosome Amplification and Aneuploidy in Human Lung Fibroblasts. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Joyce, K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces Chromosome Hypercondensation in Human Bronchial Epithelial Cells. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Karri, N.D. and Wise, Sr., J.P. Role of a Spindle Assembly Checkpoint Protein, Cdc20, in Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Keim, E., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Nickel Compounds on Marine Mammal and Human Fibroblasts. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

LaCerte, C. and Wise, Sr., J.P. Hexavalent Chromium Exposure Decreases Shugoshin1 Localization in Human Lung Fibroblasts. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Li Chen, T., Wise, S.S., Xie, H. and Wise, Sr., J.P. Hexavalent Chromium Induces DNA-Double Strand Breaks in North Atlantic Right Whale and Sperm Whale Cells. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012. 

Martino, J., Wise, S.S., Perkins, C., Kerr, I., Rowntree, V., Sironi, M. and Wise, Sr., J.P. Metal Levels in Southern Right Whale Skin Biopsies. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Sacco, J., Braun, M., Falank, L. and Wise, Sr., J.P. Nutraceuticals Protect Against Particulate Ni(II)-Induced Cytotoxicity to Human Lung Fibroblast Cells. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Wise, C.F., Wise, S.S. and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic to Sperm Whale Skin Fibroblasts. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Qin, Q., Xie, H., Holmes, A.L., Wise, S.S. and Wise, Sr., J.P. Particulate Chromate Induces Persistent DNA Double Strand Breaks Resulting in Disruption of Homologous Recombination Repair in Human Lung Cells. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Smith, L.J., Holmes, A.L. and Wise, Sr., J.P. Chronic Exposure of Cobalt Induces Cytotoxicity and Potential Genotoxicity in Human Lung Cells. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Wise, J., Wise, S.S., Xie, H. and Wise, Sr., J.P. Using Nutraceuticals to Prevent Organic Chemical Toxicity. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Wise, Jr., J.P., Wise, C.F., Keim, E. and Wise, Sr., J.P. Comparison of Observed Nickel Levels and Nickel Toxicity in Whales. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

Wise, S.S, Holmes, A.L., Xie, H., Thompson, W.D. and Wise, Sr., J.P. Hexavalent Chromium Induces Chromosome Instability Resulting in a DNA Double Strand Break Repair Deficient Phenotype and Neoplastic Transformation. Proceedings of the University of Southern Maine’s 9th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2012.

 

 

Qin, Q., Xie, H., Holmes, A.L., Wise, S.S., and Wise, Sr., J.P. Particulate Chromate Induces Persistent DNA Double Strand Breaks Resulting in Disruption of Homologous Recombination Repair in Human Lung Cells. Proceedings of the American Association for Cancer Research, 52: 514, 2012.

Xie, H., Martin, S., Wise, Sr., J.P., and Huang, S. Genotoxicity of Arsenic in Primary Human Bronchial Cells. Proceedings of the American Association for Cancer Research, 52: LB-393, 2012.

Wise, S.S., Holmes, A.L., Xie, H. Martin, S., Thompson, W.D. and Wise, Sr., J.P. Hexavalent chromium induces chromosome instability leading to DNA double strand break repair deficiency and neoplastic transformation. Proceedings of the American Association for Cancer Research, 52: 750-751, 2012.

Wise, Sr., J.P., Kerr, I, Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wise, J., Gianios, Jr., C., Wallace, B., Huang, S., LaCerte, C. and Holmes, A.L. Voyage 2 of the Odyssey: The Impact of the Oil Crisis on Health Using Whales As An Indicator Species. Toxicological Sciences, 126: 380, 2012.

Wise, J., Wise, S.S. Xie, H., Griffit, J. and Wise, Sr., J.P. Are Chemical Dispersants Used in the Gulf of Mexico Cytotoxic and Genotoxic to Human Lung and Skin Fibroblasts? Toxicological Sciences, 126: 580, 2012.

Braun, M., McKay, J.M., Wheeler C. and Wise, Sr., J.P. Simulated Microgravity Decreases Chromium (VI)-Induced Genotoxicity in Human Skin Fibroblast Cells. Toxicological Sciences, 126: 540, 2012.

Wise, C.F., Wise, S.S. and Wise, Sr., J.P. Fin Whale Cells Are More Resistant to Hexavalent Chromium than Human Cells. Toxicological Sciences, 126: 583, 2012.

Duffy, R., Holmes, A.L. and Wise, Sr., J.P. Elucidating the role of Nek2A in zinc chromate-induced centrosome amplification and aneuploidy in human lung fibroblasts. Toxicological Sciences, 126: 533-534, 2012.

Holmes, A.L. and Wise, Sr., J.P. Arsenic is Clastogenic and Aneugenic to Primary Human Urothelial Cells. Toxicological Sciences, 126: 383, 2012.

Xie, H., Martin, S., Huang, S. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Arsenic in Primary Human Lung Cells. Toxicological Sciences, 126: 314, 2012.

Falank, L., Xie, H., McGovern, D., Sample, A. Abramson, S., Perez, A., Mason, M.D., Craig, G. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Lung Cells. Toxicological Sciences, 126: 277, 2012.

Wise, Jr., J.P. Huang, S., Wheeler C. and Wise, Sr., J.P. Effects of Altered Gravity on Chromium-Induced Genotoxicity in Human Lung Cells. Toxicological Sciences, 126: 540, 2012.

Karri, N.P. and Wise, Sr., J.P. Role of a Spindle Assembly Checkpoint Protein, Cdc20, in Chromate-Induced Spindle Assembly Checkpoint Bypass. Toxicological Sciences, 126: 539, 2012.

Kerr, I and Wise, Sr., J.P. The DeepWater Horizon Disaster. Toxicological Sciences, 126: 379, 2012.

LaCerte, C., Wise, S.S. and Wise, Sr., J.P. Particulate hexavalent chromate induces a permanent phenotypic change in human lung fibroblast cells after chronic exposure. Toxicological Sciences, 126s: 2800, 2012.

McKay, J.M., Holmes, A.L., Case, C.P. and  Wise, Sr., J.P. Chronic Exposure to Hexavalent Chromium Induces Chromosome Instability in Primary Human Urothelial Cells. Toxicological Sciences, 126: 533, 2012.

Wise, S.S., Holmes, A.L., Xie, H. Martin, S., Thompson, W.D. and Wise, Sr., J.P. Hexavalent chromium induces chromosome instability resulting in a DNA double strand break repair deficient phenotype and  neoplastic transformation. Toxicological Sciences, 126: 540, 2012.

Wise, Sr., J.P. and Griffit, J. The Toxicological Impact of Metals, Crude Oil, and Chemical Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health. Toxicological Sciences, 126: 379, 2012.

Payne, R., Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Polybrominated Diphenyl Ethers Levels in Free Ranging Sperm Whale (Physeter Macrocephalus) Skin Samples from Around the Globe. Proceedings of the 19th Biennial Conference of the Biology of Marine Mammals, p.232, 2011.

Kerr, I., Payne, R. and Wise, Sr., J.P. The Research Vessel Odyssey: A Unique Platform for Marine Mammal Toxicological Research and Education. Proceedings of the 19th Biennial Conference of the Biology of Marine Mammals, p.156, 2011.

Gianios, Jr., C., Wise, Jr., J.P., Wise, C., Wise, S.S., Wallace, R., Glass, I., Walker, R., LaCerte, C.,  McKay, J., Braun, M., Wise, J., Kerr, I. and Wise, Sr., J.P. The Gulf of Mexico Offshore Toxicology Study: Marine Mammal and Other Sightings in The Two Summers Immediately Following the 2010 Gulf of Mexico Oil Crisis. Proceedings of the 19th Biennial Conference of the Biology of Marine Mammals, p.108, 2011.

Wise Sr., J.P., Wise, S.S., Kerr, I.  and Thompson, W.D. The Gulf of Mexico Offshore Toxicology Study: Chromium and Nickel Levels in Sperm Whale (Physeter macrocephalus) and Bryde’s Whale (Bryde’s edeni) Skin Tissues. Proceedings of the 19th Biennial Conference of the Biology of Marine Mammals, p.315, 2011.

Martino, J., Li Chen, T. and Wise Sr., J.P. Cytotoxicity and Genotoxicity of Chromium and Lead Compounds in Harbor Porpoise Lung Cells. Proceedings of the 19th Biennial Conference of the Biology of Marine Mammals, p.192, 2011.

Savery, L.C., Evers, D., Wise, S.S., Falank, C., Wise, J., Gianios, Jr., C., Kerr, I., Payne, R. Thompson, W.D., Perkins, C., Zheng, T., Zhu, C., Benedict, L. and Wise, Sr., J.P. Global Mercury and Selenium Concentrations in Skin from Free-Ranging Sperm Whales (Physeter macrocephalus). Science of the Total Environment 450–451: 59–71, 2013.

Wise, Jr., J.P., Wise, S.S., Kerr, I. and Wise, Sr., J.P. Assessing the Potential Effects of the Gulf of Mexico Oil Disaster using Sperm Whale Karyotypes. Proceedings of the 19th Biennial Conference of the Biology of Marine Mammals, p. 315, 2011.

Wise, Jr., J.P., Xie, H., Wallace, W., Jeevarajan, A., Jenniskens, P., Shaddad, M.H. and Wise, Sr., J.P. Toxicity of Simulated Martian and Lunar Dusts, Earth and Asteroidal Dust in Human Lung Cells. Proceedings of the annual meeting of the American Society for Gravitational and Space Biology, p 80, 2011.

Wise, Sr., J.P., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, S.S., Wise, J., Gianios, Jr., C., Wallace, B., Glass, I., Walker, R., LaCerte, C. and Holmes, A.L. Voyage 2 of the Odyssey: the Impact of the Oil Crisis on Health Using Whales as an Indicator Species. To be presented at the annual meeting of the Environmental Mutagen Society, October 2011.

Wise, S.S., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Gianios Jr., C., Braun, M., Wallace, B., Walker, R., LaCerte, C., McKay, J.M. and Wise, Sr., J.P. The Impact of the Gulf Oil Crisis on Whales. Presented at the 16th International Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.

Wise, Jr. J.P., Wise, S.S. and Wise, Sr., J.P. The Use of Sperm Whale Karyotype to Assess the Potential Impacts of the Gulf of Mexico Oil Spill. Presented at the 16th International Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.

Wise, J., McKay, J.M., Lacerte, C., Walter, R.B. and Wise Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Medaka Cells. Presented at the 16th International Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.

Wise, C.F., Wise, S.S.  and Wise, Sr. J.P. Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic and Genotoxic to Sperm Whale Skin Fibroblasts. Presented at the 16th International Symposium on Pollutant Responses in Marine Organisms (PRIMO), May 2011.

Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Global Assessment of Polybrominated Diphenyl Ethers in Sperm Whale (Physeter Macrocephalus) Skin. Toxicological Sciences, 120: 403, 2011.

Chen, T., Martino, J., Wise, S.S., LaCerte, C., Shaffiey, F., Xie, H., Holmes, A.L., McPhearson, K., Kerr, I., Payne, R., Kraus, S.D. and Wise, Sr., J.P. The Toxic Effects of Chromium Compounds in North Atlantic Right Whale and Sperm Whale Cells. Toxicological Sciences, 120: 516, 2011.

Wise, S.S., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Gianios, Jr., C., Braun, M., Wallace, B., Glass, I., Walker, R., LaCerte, C., McKay, J., Chen, T., Martino, J., Chapman, G., Duffy, R., Leighton, R., Joyce, K. and Wise, Sr., J.P. The Gulf Oil Crisis: Impact on Whales. Toxicological Sciences, 120: 514, 2011.

Martino, J., Wise, S.S., Holmes, A.L., Xie, H. and Wise, Sr., J.P. Bowhead Whale Lung Cells Are Resistant to Cr(IV)-Induced Genotoxicity. Toxicological Sciences, 120: 59, 2011.

Kerr, I. and Wise, Sr., J.P. The Voyages of the Odyssey: A Unique Platform for Toxicological Research and Education. Toxicological Sciences, 120: 400, 2011.

Joyce, K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces Selective X-Chromosome Fragmentation Dependent on XRCC3 in Chinese Hamster Ovary Cells. Toxicological Sciences, 120: 60, 2011.

Wise, Jr., J.P., Wheeler, C. and Wise, Sr., J.P. The Impact of Altered Gravity on Chromate Genotoxicity: Using a Bioreactor to Simulate Microgravity in Cell Culture. Toxicological Sciences, 120: 60, 2011.

Wise, J., Wise, S., Xie, H. and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic and Genotoxic to Human Skin Fibroblasts. Toxicological Sciences, 120: 503, 2011.

Xie, H., McGovern, D., Sample, A., Abramson, S., Perez, A., Falank, L., Mason, M.D., Graig, G. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Acute and Chronic Exposure to Silver Nanoparticles in Human Lung Cells. Toxicological Sciences, 120: 464, 2011.

Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Chronic Exposure to Particulate Chromate Induces Numerical Chromosome Instability and Centrosome Amplification in  Human Lung Cells. Toxicological Sciences, 120: 59, 2011.

Duffy, R., Wise, J., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Sheheta, T. and Wise, Sr., J.P. Lunar Dust Simulant is Cytotoxic but Not Genotoxic to Human Skin Fibroblast Cells. Toxicological Sciences, 120: 64, 2011.

Wise, C.F., Braun, M., Wise, Jr., J.P., Wise, J., Wise, S.S., Kerr, I., Xie, H. and Wise, Sr., J.P. Developing a Whale Cell Line at Sea to Evaluate the Cytotoxicity and Genotoxicity of Chemical Dispersants Used in the Gulf Of Mexico Oil Crisis. Toxicological Sciences, 120: 503, 2011.

LaCerte, C., Chen, T., Holmes, A., Wise, S., Kraus, S., Gulland, F.M.D. and Wise, Sr., J.P. Comparison of Chromium Toxicity on Human, Steller Sea Lion, Sperm Whale and Northern Right Whale Skin Cells. Toxicological Sciences, 120: 517, 2011.

Braun, M., Qin, Q., Xie, H., Leighton, R., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Sheheta, T. and Wise, Sr., J.P. Comparative Cytotoxicity of Simulated Moon and Mars Dusts, Earth Dust and Selected Lunar Dust Components in Human Lung Epithelial Cells. Toxicological Sciences, 120: 65, 2011.

Xie, H., LaCerte, C., Joyce, K. and Wise, Sr., J.P. Depleted Uranium Induces Chromosome Instability and Epigenetic Modification in Human Lung Epithelial Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, p. 126, 2011.

Qin Q., Holmes, A.L., Xie, H., Wise, S.S., and Wise, Sr., J.P. Particulate Chromate Induces Chromosome Instability by Disrupting Normal DNA Double Strand Break Repair and Cell Cycle Regulation in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, p. 109, 2011.

Wise, S.S., Holmes, A.L., Xie, H., Martin, S.,  Pelsue, S.C., Thompson, W.D., and Wise Sr, J.P. Hexavalent chromium induces chromosome instability resulting in a DNA double strand break repair deficient phenotype and neoplastic transformation. Proceedings of the Keystone Symposia on Genomic Instability and Repair, p.125, 2011.

Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Global Assessment of Polybrominated Diphenyl Ethers in Sperm Whale (Physeter Macrocephalus) Skin. Program of the National Council for Science and the Environment's (NCSE) 11th National Conference on Science, Policy, and the Environment, p. 50, 2011.

Wise Sr, J.P., Wise, S.S., LaCerte, C., Li Chen, T., Wise, J., Gianios, Jr, C., Payne, R., Kerr, I. and Thompson, W. D. Chromium Is a Global Concern for Sperm Whales (Physeter macrocephalus). Program of the National Council for Science and the Environment's (NCSE) 11th National Conference on Science, Policy, and the Environment, p. 49, 2011.

Wise, S.S., Wise, Jr., J.P., Braun, M., Wise, C.F., Wise, J., Gianios, Jr, C., Huang, S., Wallace, B., Glass, I., Walker, R., LaCerte, C., McKay, J., Kerr, I., Payne, R., and Wise Sr, J.P. Assessing the Impact of the Deepwater Horizon Oil Spill on Whales. Program of the National Council for Science and the Environment's (NCSE) 11th National Conference on Science, Policy, and the Environment, p.49, 2011.

Holmes, A., Wise S., Pelsue S., Lingle, W., Salisbury, J. and Wise, Sr., J.P.  Chronic Exposure to Particulate Chromate Induces Numerical Chromosome Instability and Centrosome Amplification in Human Lung Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, S., Kerr, I,  Wise, Jr., J.P.,  Wise, C., Wise, J., Gianios, Jr., C., Braun, M., Wallace, R., Glass, I., Walker, R., LaCerte, C., McKay, J., Li Chen, T., Martino, J., Chapman, G., Duffy, R., Leighton, R., Joyce, K. and Wise, Sr., J.P. The Gulf Oil Crisis: Impact on Whales. Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, Jr, J.P., Wise, S. and Wise, Sr., J.P. The Use Of Sperm Whale Karyotype To Assess The Potential Impacts Of The Gulf Of Mexico Oil Spill. Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, Jr., J.P., Wheeler, C. and Wise, Sr., J.P. The Impact of Altered Gravity on Chromate Genotoxicity: Using a Bioreactor to Simulate Microgravity in Cell Culture.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Shively, E., Wise, Jr., J.P., McKay, J. and Wise, Sr., J.P.  The Effect of Hypergravity on Cr(VI)-induced Cytotoxicity and Genotoxicity.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

LaCerte, C., Li Chen, T., Holmes, A., Wise, S., Kraus, S., Gulland, F. and Wise, Sr., J.P. Comparison of Chromium Toxicity on Human, Steller Sea Lion, Sperm Whale and Northern Right Whale Skin Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, C., Kreps, D., Wise, S. and Wise, Sr., J.P.  Using Natural Products to Prevent the Toxic Effects of Chemicals in Altered Gravity.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, C., Braun, M., Wise, Jr., J.P., Wise, J., Wise, S., Kerr, I., Xie, H. and Wise, Sr., J.P. Developing a Whale Cell Line at Sea to Evaluate the Cytotoxicity and Genotoxicity of Chemical Dispersants Used in the Gulf of Mexico Oil Crisis.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Kreps, D., Wise. C., Wise, S. and Wise, Sr., J.P. Using Blueberry Extract to Prevent Arsenic Toxicity. Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011. 

Kari, N., Holmes, A. and Wise, Sr., J.P. Role of Cdc20 Spindle Assembly Checkpoint Protein in Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Martino, J., Wise, S., Holmes, A., Xie, H. and Wise, Sr., J.P. Hexavalent Chromium Genotoxicity in Human and Bowhead Whale Lung Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Qin, Q., Holmes, A., Xie, H., Wise, S. and Wise, Sr., J.P. Particulate Chromate Induces Chromosome Instability by Disrupting Normal DNA Double Strand Break Repair and Cell Cycle Regulation in Human Lung Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Li Chen, T., Martino, J., Wise, S., LaCerte, C., Shaffiey, F., Xie, H., Holmes, A., McPhearson, K., Kerr, I., Payne, R., Kraus, S. and Wise, Sr., J.P. The Toxic Effects of Chromium Compounds in North Atlantic Right Whale and Sperm Whale Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, J., Wise, S., Xie, H. and Wise, Sr., J.P. Using Nutraceuticals to Prevent Organic Chemical Toxicity. Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Wise, J., Wise, S., Xie, H., Griffit, J. and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic and Genotoxic to Human Skin Fibroblasts.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Lake, G., Xie, H., LaCerte, C., Martino, J., Leighton, R., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Toxicity of Lunar Dust Simulant and Lunar Dust Components on Human Brain Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Duffy, R., Wise, J., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Lunar Dust Simulant is Cytotoxic but Not Genotoxic to Human Skin Fibroblast Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Merrill, N., McKay, J. and Wise, Sr., J.P. Does Elderberry Syrup Help Protect Human Lung Cells From Chromate-Induced Toxicity?  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Braun, M., Leighton, R., Xie, H., Bickford, M., Lake, F., Mason, M., Jeevarajan, A., Wallace, W.,Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Cytotoxicity and Genotoxicity of Mars, Earth and Moon Dusts in Human Skin Epithelial Cells.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Braun, M., Wheeler, C., Shehata, T. and Wise, Sr., J.P. Using Microcarriers and a Bioreactor to Support Cell Growth in a Simulated Microgravity Environment.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Joyce. K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces Selective X-Chromosome Fragmentation in Chinese Hamster Ovary Cells Dependent on XRCC3.  Proceedings of the University of Southern Maine’s 8th Annual Thinking Matters Conference:  USM Research, Scholarship, and Creativity Symposium, April, 2011.

Braun, M., Qin, Q., Xie, H., Leighton, R., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Sheheta, T. and Wise, Sr., J.P. Comparative Cytotoxicity of Simulated Moon and Mars Dusts, Earth Dust and Selected Lunar Dust Components in Human Lung Epithelial Cells. Toxicological Sciences, 120: 65, 2011.

LaCerte, C., Chen, T., Holmes, A., Wise, S., Kraus, S., Gulland, F.M.D. and Wise, Sr., J.P. Comparison of Chromium Toxicity on Human, Steller Sea Lion, Sperm Whale and Northern Right Whale Skin Cells. Toxicological Sciences, 120: 517, 2011.

Wise, C.F., Braun, M., Wise, Jr., J.P., Wise, J., Wise, S.S., Kerr, I., Xie, H. and Wise, Sr., J.P. Developing a Whale Cell Line at Sea to Evaluate the Cytotoxicity and Genotoxicity of Chemical Dispersants Used in the Gulf Of Mexico Oil Crisis. Toxicological Sciences, 120: 503, 2011.

Duffy, R., Wise, J., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Sheheta, T. and Wise, Sr., J.P. Lunar Dust Simulant is Cytotoxic but Not Genotoxic to Human Skin Fibroblast Cells. Toxicological Sciences, 120: 64, 2011.

Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Chronic Exposure to Particulate Chromate Induces Numerical Chromosome Instability and Centrosome Amplification in Human Lung Cells. Toxicological Sciences, 120: 59, 2011.

Xie, H., McGovern, D., Sample, A., Abramson, S., Perez, A., Mason, M.D., Graig, G. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Acute and Chronic Exposure to Silver Nanoparticles in Human Lung Cells. Toxicological Sciences, 120: 464, 2011.

Wise, J., Wise, S., Xie, H. and Wise, Sr., J.P. Chemical Dispersants Used in the Gulf of Mexico Are Cytotoxic and Genotoxic to Human Skin Fibroblasts. Toxicological Sciences, 120: 503, 2011.

Wise, Jr., J.P., Wheeler, C. and Wise, Sr., J.P. The Impact of Altered Gravity on Chromate Genotoxicity: Using a Bioreactor to Simulate Microgravity in Cell Culture. Toxicological Sciences, 120: 60, 2011.

Joyce, K., LaCerte, C. and Wise, Sr., J.P. Particulate Depleted Uranium Induces Selective X-Chromosome Fragmentation Dependent on XRCC3 in Chinese Hamster Ovary Cells. Toxicological Sciences, 120: 60, 2011.

Kerr, I. and Wise, Sr., J.P. The Voyages of the Odyssey: A Unique Platform for Toxicological Research and Education. Toxicological Sciences, 120: 400, 2011.

Martino, J., Wise, S.S., Holmes, A.L., Xie, H. and Wise, Sr., J.P. Bowhead Whale Lung Cells Are Resistant to Cr(IV)-Induced Genotoxicity. Toxicological Sciences, 120: 59, 2011.  

Wise, S.S., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Gianios, Jr., C., Braun, M., Wallace, B., Glass, I., Walker, R., LaCerte, C., McKay, J., Chen, T., Martino, J., Chapman, G., Duffy, R., Leighton, R., Joyce, K. and Wise, Sr., J.P. The Gulf Oil Crisis: Impact on Whales. Toxicological Sciences, 120: 514, 2011.

Chen, T., Martino, J., Wise, S.S., LaCerte, C., Shaffiey, F., Xie, H., Holmes, A.L., McPhearson, K., Kerr, I., Payne, R., Kraus, S.D. and Wise, Sr., J.P. The Toxic Effects of Chromium Compounds in North Atlantic Right Whale and Sperm Whale Cells. Toxicological Sciences, 120: 516, 2011.

Savery, L.C., Eagle, S., Stapleton, H.M., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Global Assessment of Polybrominated Diphenyl Ethers in Sperm Whale (Physeter Macrocephalus) Skin. Toxicological Sciences, 120: 403, 2011.

Wise, S.S., Holmes, A.L., Xie, H., Martin, S.,  Pelsue, S.C., Thompson, W.D., and Wise Sr, J.P. Hexavalent chromium induces chromosome instability resulting in a DNA double strand break repair deficient phenotype and neoplastic transformation. Proceedings of the Keystone Symposia on Genomic Instability and Repair, p.125, 2011. 

Qin Q., Holmes, A.L., Xie, H., Wise, S.S., and Wise, Sr., J.P. Particulate Chromate Induces Chromosome Instability by Disrupting Normal DNA Double Strand Break Repair and Cell Cycle Regulation in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, p. 109, 2011.

Xie, H., LaCerte, C., Joyce, K. and Wise, Sr., J.P. Depleted Uranium Induces Chromosome Instability and Epigenetic Modification in Human Lung Epithelial Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, p. 126, 2011.

 

2006-2010

Wise, Sr., J.P., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Wise, S.S., Gianios, Jr., C., Braun, M., Martino, J., Chen, T., LaCerte, C., Duffy, R. and Joyce, K. The Impact of the Gulf Oil Crisis on Cetaceans: Establishing a Baseline of Toxicology Data for Sperm Whales and Bryde's Whales in the Gulf of Mexico. Presented at the Collaborative Scientific Research in Relation to the Gulf Oil Spill, November, 2010. 

Wise, Sr., J.P., Kerr, I., Wise, Jr., J.P., Wise, C.F., Wise, J., Wise, S.S., Gianios, Jr., C., Braun, M., Davenport, J., Chapman, G., Duffy, R., Leighton, R., Martino, J., Chen, T., LaCerte, C., Joyce, K. And Wray, G. The Impact of the Gulf Oil Crisis on Whales: Establishing a Baseline of Toxicology Data in the Gulf. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 381, 2010.

Wise, Jr., J.P., Braun, M., Wise, C.F., Wise, J., Wise, S.S., Gianios, Jr., C., LaCerte, C., Chen, T., Huang, S., Martino, J., Holmes, A.L., McKay, J., Joyce, K. and Wise, Sr., J.P. Voyage II of the Odyssey: An expedition to study whales in the Gulf of Mexico in response to the Gulf oil crisis. Presented at the 2nd Annual Civic Matters Conference, November, 2010.

Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Mechanism of Particulate Chromate-Induced Chromosome Instability in Human Lung Cells. Presented at the 6th Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, November, 2010.

 Xie, H., LaCerte, C. and Wise, Sr., J.P. Mechanism of Depleted Uranium-induced Neoplastic Transformation in Human Lung Epithelial Cells. Presented at the 6th Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, November, 2010.

Wise, S.S., Holmes, A.L., Xie, H., Martin, S.,  Pelsue, S.C., Thompson, W.D., and Wise Sr, J.P. Repeated Particulate Chromate Exposure Induces Chromosome Instability and a Subsequent DNA Double Strand Break Repair Deficient Phenotype and Neoplastic Transformation. Presented at the 6th Conference on Molecular Mechanism of Metal Toxicity and Carcinogenesis, Lexington, KY, November 2010.

Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J. and Wise, Sr., J.P. Zinc Chromate Induces Chromosome Instability and Centrosome Amplification in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, 2, October, 2010.

Xie, H., McGovern, D., Sample, A., Abramson, S., Perez, A., Mason, M.D., Craig, G. and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, 13, October, 2010.

Wise, J., Wise, S.S., Xie, H. and Wise, Sr., J.P. Chemical Dispersants in the Gulf of Mexico Are Cytotoxic and Genotoxic to Human Skin Fibroblasts. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, 16, October, 2010.

Eagle, S.D., Stapleton, H.M., Kerr, I. and Wise, Sr., J.P. Geographic Variation in the Concentrations of Polybrominated Diphenyl Ethers (PBDEs) and Methoyxlated PBDEs In Sperm Whale .(Physeter macrocephalus) Blubber. Presented at the 30th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin 2010), September, 2010.

Ather, A., Ma, Y., Reynolds, J., Wise, Sr., J.P., Inzucchi, S. and Katz, D. L. Chromium Effects on Glucose Tolerance, Insulin Sensitivity and Vascular Function in People at Risk for Diabetes. Presented at the 70th Scientific Sessions of the American Diabetes Association, June, 2010.

Holmes, A.L, Wise, S.S., Sandwick, S.J., Lingle, W., Salisbury, J., Wise, Sr., J.P. Mechanism of Hexavalent Chromium-Induced Chromosome Instability and Centrosome Amplification. Proceedings of the 8th International Chromosome Segregation and Aneuploidy Workshop, 54, 2010.

Wise, S.S., Holmes, A.L, Xie, H., Pelsue, S., Thompson, W.D., Wise, Sr., J.P. Repeated Acute Exposure to Particulate Chromate Disrupts Mitosis to Induce Numerical and Structural Chromosome Instability in Human Lung Cells. Proceedings of the 8th International Chromosome Segregation and Aneuploidy Workshop, 38, 2010.

Wise, Sr., J.P., Holmes, A.L, Wise, S.S., Lingle, W., Salisbury, J. Mechanism of Hexavalent Chromium-Induced Chromosome Instability and Centrosome Amplification. Proceedings of the 8th International Chromosome Segregation and Aneuploidy Workshop, 11, 2010.

Li Chen, T., LaCerte, C., Shaffiey, F., Wise, S.S., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Hexavalent Chromium is More Clastogenic to Human Skin Fibroblasts than to Sperm Whale Skin Fibroblasts. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Savery, L.C., O’Brien, T.J., Holmes, A.L., Wise, Sr., J.P. and Patierno, S.R. Nucleotide Excision Repair Contributes to Hexavalent Chromium-Induced Double Strand Breaks and Chromosomal Damage. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Doering, A., Wise, S.S, LaCerte, C., Chen, T.L, Martino, J., Martin, P., McGovern, D., Sample, A., Bickford, M,  Goodwin, T.J., O’Hara, T. and Wise, Sr., J.P. Bowhead (Balaena mysticetus) Lung Cells are Resistant to Chromium-Induced Damage. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Doucette, C.R., Holmes, A.L., and Wise, Sr., J.P. Mitotic Arrest Deficient (MAD) Protein Localization during Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Karri, N.D., Holmes, A.L., and Wise, Sr., J.P. Role of Cdc20 and BubR1 Spindle Assembly Checkpoint Proteins in Chromate-Induced Spindle Assembly Checkpoint Bypass. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

LaCerte, C., Holmes, A.L., Wise, S., and Wise, Sr., J.P. During Which Division Does Chronic Exposure to Hexavalent Chromium Induce Chromosome Instability in Human Lung Cells? Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Martino, J., Wise, S.S., Holmes, A.L., Xie, H., and Wise, Sr., J.P. Bowhead Whale Lung Cells Are Resistant to Cr-induced Genotoxicity Potential Mechanisms. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Qin, Q., Holmes, A.L., Xie, H., Wise, S.S., and Wise, Sr., J.P. Chronic Exposure to Zinc Chromate Induces DNA Double Strand Breaks in Human Lung Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J., Gallagher, J. and Wise, Sr., J.P. Prolonged Exposure to Zinc Chromate Induces Numerical Chromosome Instability via Centrosome Amplification in Human Lung Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference USM Research, Scholarship, and Creativity Symposium, April, 2010.

Wise, C.F., Wise, S.S., Li Chen, T., Mate, B.R., Kraus, S., Thompson, W.D. and Wise, Sr., J.P. A Tale of Two Whales: Toxic Effects of Hexavalent Chromium in Right Whale (Eubalaena glacialis) and Blue Whale (Balaenoptera musculus). Cells Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Davenport, J.A., Li Chen, T., Wise, S.S., Payne, R., Kerr, I. and Wise, Sr., J.P. Trivalent Chromium is Clastogenic to Sperm Whale Skin Fibroblasts. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Wise, Jr., J.P., Wise, S.S., Wise, J., McKay, J., Browne, M., Joyce, K., Braun, M., Wise, C.F., Duffy, R., Estell, E., Brown, J., Gianios, Jr., C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Kreps, D., Wise, C.F., Wise, S.S. and Wise, Sr., J.P. Using Blueberry Extract to Prevent Arsenic Toxicity. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Braun, M., Leighton, R., Xie, H., Bickford, M., Lake, G.,  Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Cytotoxicity and Genotoxicity of Mars, Earth and Moon Dusts in Human Skin Epithelial Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Wise, J., Duffy, R., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Lunar, Martian and Earth Dusts in Human Skin Fibroblast Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Joyce, K., LaCerte, C. and Wise, Sr., J.P. Depleted Uranium Induces Chromosome Hypercondensation in Human Bronchial Epithelial Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Lake, G., Xie, H., LaCerte, C., Martino, J., Leighton, R., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P.  Toxicity of Lunar Dust on Human Brain Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

McKay, J. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced Toxicity in Bowhead Whale Lung Cells and Medaka Fish Fin Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Duffy, R., Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Short-Term and Chronic Exposure to Lunar Dust and Its Component Particles in Human Skin Fibroblast Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Shively, B., Wise, Jr., J.P., Richardson, B., Krieg, E., Bickford, M. and Wise, Sr., J.P.  Mars Dust is Genotoxic to Human Lung Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Wheeler, C., Wise, Jr., J.P.  and Wise, Sr., J.P. Effects of Simulated Microgravity on Chromate Toxicity in Human Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Wise, S.S., Holmes, A.L, Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P. Repeated Particulate Chromate Exposure Induces Chromosome Instability and a DNA Double Strand Break Repair-Deficient Phenotype in Human Lung Cells. Proceedings of the University of Southern Maine’s 7th Annual Thinking Matters Conference: USM Research, Scholarship, and Creativity Symposium, April, 2010.

Wise, Jr. J.P., Wise, S., Wise, J., Wise, C., McKay, J., Braun, M., Courtemanche, A., Joyce, K., Freedman, B., Browne, M., Estell, E., Brown, J., Gianios, Jr. C., Mason, M., Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Chromosome Damage in Human Lung Cells. Proceedings of the 2nd Annual Northeast Undergraduate Research Development Symposium, University of New England, April, 2010.

Wise, J., Duffy, R., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., and Wise, Sr., J.P. Comparative Toxicity of Lunar, Martian and Earth Dusts in Human Skin Fibroblast Cells. Proceedings of the 2nd Annual Northeast Undergraduate Research Development Symposium, University of New England, April, 2010.

Lake, G., Xie, H., LaCerte, C., Martino, J., Leighton, R., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T., and Wise, Sr., J.P. Toxicity of Lunar Dust Simulant on Human Brain Cells. Proceedings of the 2nd Annual Northeast Undergraduate Research Development Symposium, University of New England, April, 2010.

Duffy, R., Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T., and Wise, Sr., J.P. Comparative Toxicity of Short-Term and Chronic Exposure to Lunar Dust and Its Component Particles in Human Skin Fibroblast Cells. Proceedings of the 2nd Annual Northeast Undergraduate Research Development Symposium, University of New England, April, 2010.

Braun, M., Leighton, R., Xie, H., Bickford, M., Lake, G., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T., and Wise, Sr., J.P. Comparative Cytotoxicity and Genotoxicity of Mars, Earth, and Moon Dusts in Human Skin Epithelial Cells. Proceedings of the 2nd Annual Northeast Undergraduate Research Development Symposium, University of New England, April, 2010.

Savery, L.C., O’Brien, T.J., Holmes, A.L., Wise, Sr., J.P., Patierno, S.R. Nucleotide Excision Repair Contributes to Hexavalent Chromium- Induced Double Strand Breaks and Chromosomal Damage. Proceedings of the American Association for Cancer Research, 51: 2978, 2010.

Xie, H., LaCerte, C. and Wise, Sr., J.P. Epigenetic Mechanism Is Involved in Depleted Uranium-induced Transformation in Human Lung Epithelial Cells. Proceedings of the American Association for Cancer Research, 51: 3464, 2010.

Holmes, A.L., Wise, S.S., Pelsue, S., Lingle, W., Salisbury, J., Gallagher, J. and Wise, Sr., J.P. Prolonged Exposure to Zinc Chromate Induces Numerical Chromosome Instability via Centrosome Amplification in Human Lung Cells. Proceedings of the American Association for Cancer Research, 51: 3473, 2010.

Wise, S.S., Holmes, A.L., Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P. Repeated Particulate Chromate Exposure Induces Chromosome Instability and a DNA Double Strand Break Repair-Deficient Phenotype in Human Lung Cells. Proceedings of the American Association for Cancer Research, 51: 3467, 2010.

Xie, H., LaCerte, C. and Wise, Sr., J.P. Study on Mechanism for Depleted Uranium-induced Transformation in Human Lung Epithelial Cells. Toxicological Sciences, 114: 2170, 2010.

Wise, J., Duffy, R., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond. D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Lunar, Martian and Earth Dusts in Human Skin Fibroblast Cells. Toxicological Sciences, 114: 375, 2010.

Wise, Jr., J.P., Wise, S. S., Wise, J., Mckay, J., Browne, M., Joyce, K., Braun, M., Wise, C., Duffy, R., Estell, E., Brown, J., Gianios Jr., C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Simulated Spaceflight Increases Chromate-Induced Genotoxicity. Toxicological Sciences, 114: 1125, 2010.

Duffy, R. Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond. D., Shehata, T. and Wise, Sr., J.P. Comparative Toxicity of Short-Term and Chronic Exposure to Lunar Dust and Its Component Particles in Human Skin Fibroblast Cells. Toxicological Sciences, 114: 292, 2010.

Wise, S.S, Xie, H., Holmes, A.L., Wise, C.F., Doering, A., McGovern, D., Sample, A., Stevenson, M., Merrill, N., Chen, T.L., Martino, J., Bickford, M., Goodwin, T.J., O’Hara, T. and Wise, Sr., J.P. Bowhead (Balaena mysticetus) Lung Cells are Resistant to Chromium-Induced Damage. Toxicological Sciences, 114: 1128, 2010.

Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Browne, M., Joyce, K., Braun, M., Wise, C., Duffy, R., Estell, E., Brown, J., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity. Gravitational and Space Biology 23(1): 32, 2009.

Wise, Jr., J.P., Wise, S.S., Mason, M.D., Li Chen, T., LaCerte C., Craig, G., Walter, R., Payne, R., Kerr, I., Kraus, S. and Wise, Sr., J.P. Toxicity of Silver Nanoparticles in Human, Marine Mammal and Fish Cells. Proceedings of the 2nd USAF ASC/AFRL ESOH Nanomaterial Workshop, 2009.

Alexander, A.M., Payne, R., Kerr, I., Wise, Sr., J.P., Steel, D., Baker, C.S. Circum-equatorial survey of mtDNA diversity in the sperm whale (Physeter macrocephalus): Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p.11, 2009.

Payne, R., LaCerte, C., Wise, S.S., Gianios, Jr., C, Wise, J., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Tin Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p.196, 2009.

Li Chen, T., LaCerte, C., Shaffiey, F., Wise, S.S., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Sperm Whale Skin Fibroblasts Are More Resistant to Hexavalent Chromium Toxicity than Human Skin Fibroblasts. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 143, 2009.

Wise, S.S., Mason, M.D., LaCerte, C., Li Chen, T., Craig, G., Walter, R., Payne, R., Kerr, I., Gianios, Jr., C., Wise, J., Thompson, W.D. and Wise, Sr., J.P. Silver nanoparticle toxicity in sperm whale (Physeter macrocephalus) cells and global distribution of silver levels in sperm whale skin tissue. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 278, 2009.

McNamara, L., Wise, S.S., LaCerte, C., Gianios, Jr., C.. Wise, J., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Nickel Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 162, 2009.

Cain, S., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Marine Mammal Sightings in the Indian Ocean Observed During the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 46, 2009.

Martino, J., Wise, S.S., Holmes, A.L., Thompson, W.D. and Wise, Sr., J.P. Hexavalent Chromium Is More Cytotoxic but Less Genotoxic to Bowhead Whale Lung Fibroblasts than Human Lung Fibroblasts. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 155, 2009.

Wise, Jr., J.P., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I., Thompson, W.D., Mason, M.D. and Wise, Sr., J.P. Gold and Titanium Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 278, 2009.

Wise, Sr., J.P., Wise, S.S., LaCerte, C., Li Chen, T., Wise, J., Gianios, Jr., C., Payne, R., Kerr, I. and Thompson, W.D. Genotoxicity and Global Distribution of Chromium in Sperm Whale (Physeter macrocephalus) Skin Cells and Tissues. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 279, 2009.

Gianios, Jr., C., LaCerte, C., Wise, S.S., Wise, J., Payne, R., Kerr, I., Thompson, W.D. and Wise Wise, Sr., J.P. Marine Mammal Sightings in the Pacific Ocean Observed During the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 90, 2009.

Wise, C.F., Wise, S.S., Li Chen, T., Mate, B.R., Kraus, S., Thompson, W.D. and Wise, Sr., J.P. A Tale of Two Whales: Toxic Effects of Hexavalent Chromium in Right Whale (Eubalaena glacialis) and Blue Whale (Balaenoptera musculus) Cells. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 278, 2009.

LaCerte, C., Wise, S.S., Shaffiey, F., Li Chen, T., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Comparison of Chromium Toxicity in Cells from Sperm Whales (Physeter macrocephalus) and Steller Sea Lions (Eumetopias jubatus). Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 136, 2009.

Kerr, I., LaCerte, C. Wise, S.S., Gianios, Jr., C., Wise, J., Evers, D., Payne, R., Thompson, W.D. and Wise, Sr., J.P. Mercury Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 128, 2009.

Wise, J., LaCerte, C., Wise, S.S., Gianios, Jr., C., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Lead Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 278, 2009.

Hayes, M., Wise, S.S., LaCerte, C., Gianios, Jr., C. Wise, J., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Copper Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 109, 2009.

Marshall, K., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R. Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Cadmium Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 153, 2009.

Knowlton, C., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Barium Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 130 , 2009.

Atkinson, J., LaCerte, C., Wise, S.S., Gianios, Jr., C., Wise, J., Payne, R., Kerr, I., Thompson, W.D. and Wise, Sr., J.P. Arsenic Levels in Sperm Whale (Physeter macrocephalus) Skin Biopsies Collected from around the Globe during the Voyage of the Odyssey. Proceedings of the 18th Biennial Conference of the Biology of Marine Mammals, p. 20, 2009.

Chun, G., Wise, S.S., Wise Sr., J.P. Holmes, A.L., Patierno, S.R. and Ceryak, S.M. Protein tyrosine phosphatase inhibition enhances survival and chromosomal stability after genotoxin exposure at the expense of increased mutagenesis. Proceedings of the American Association for Cancer Research 50: 464, 2009.

Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond, D., Wise, Sr.,J.P. Arsenic Synergistically Increases Zinc Chromate-Induced Aneuploidy and Spindle Assembly Checkpoint Bypass in Human Lung Cells. Proceedings of the 36th Annual Biological and Medical Science Symposium, April, 2009.

McKay, J., Wise, Jr., J.P. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced Toxicity in Bowhead Whale Lung Cells. Proceedings of the 36th Annual Biological and Medical Science Symposium, April, 2009

Young, J.L., Holmes, A.L., Qin, Q., Xie, H. and Wise, Sr., J.P. Zinc Chromate Induced Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells. Proceedings of the 36th Annual Biological and Medical Science Symposium, April, 2009.

Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne, M., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity. Proceedings of the 36th Maine Biological and Medical Sciences Symposium, April, 2009.

LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Transformation in Human Lung Epithelial Cells. Proceedings of the 36th Maine Biological and Medical Sciences Symposium, April, 2009.

Martino, J., Wise, Jr., J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung Fibroblasts. Proceedings of the 36th Maine Biological and Medical Sciences Symposium, April, 2009.

Wise, Jr. J.P., Wise, S.S., Wise, J., Wise, C., McKay, J., Braun, M., Courtemanche, A., Freedman, B., Browne, M., Hamilton, I., Brown, J., Gianios, Jr. C., Mason, M. and Wise, Sr., J.P. Dirigo, Maine’s First Student Team Aboard the Weightless Wonder: Effects of Altered Gravity on Cellular Function. Proceedings of the 1st Annual Northeast Undergraduate Research Development Symposium, March, 2009.

Wise, J., Wise S.S., and Wise, Sr., J.P. Development of Amphibian Cell Lines for Toxicological Studies. Proceedings of the 1st Annual Northeast Undergraduate Research Development Symposium, March, 2009.

McKay, J., Wise, Jr., J.P. and Wise, Sr., J.P. Effects of Hypergravity on Chromate-Induced Toxicity in Bowhead Whale Lung Cells. Proceedings of the 1st Annual Northeast Undergraduate Research Development Symposium, March, 2009.

Duffy, R., Wise, J., LaCerte, C., Xie, H., Huang, J., Mckay, J., Bickford, M., Okeny, M., Bousfield, D., Mason, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Humans and Fish? Proceedings of the 1st Annual Northeast Undergraduate Research Development Symposium, March, 2009.

Wise, Sr., J.P. and De Guise, S. Aquatic Species as Sentinels for Human Health: Comparative Toxicology of Metals, Nanoparticles and PCBs. Toxicological Sciences 108: 1220, 2009.

Duffy, R., Wise, J., Xie, H., LaCerte, C., Mason, M., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Cytotoxicity of Lunar Dust to Human Skin Fibroblast Cells. Toxicological Sciences 108: 2305, 2009.

Wise, S.S., Li Chen, T., LaCerte, C., Martino, J., Doering, A., Martin, P., McGovern, D., Sample, A., Bickford, M., Goodwin, T.J., O’Hara, T. and Wise, Sr., J.P. Hexavalent Chromium Is More Clastogenic to Human Cells than Bowhead Whale (Balaena mysticetus) Cells. Toxicological Sciences 108: 1785, 2009.

Qin, Q., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Particulate Chromate Induced DNA Double Strand Breaks Are Associated with XPF Gene Activity in Human Lung Cells. Toxicological Sciences 108: 735, 2009.

Xie, H., LaCerte, C. and Wise, Sr., J.P. Mechanism of Carcinogenicity of Depleted Uranium in Human Lung Epithelial Cells. Toxicological Sciences 108: 734, 2009.

Martino, J., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung Fibroblasts. Toxicological Sciences 108: 1787, 2009.

Young, J.L., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T. and Wise, Sr., J.P. Lunar Dust and its Components are Cytotoxic to Human Lung Cells. Toxicological Sciences 108: 1778, 2009.

Wise, J.T., LaCerte, C., Xie, H., Huang, J., McKay, J., Bickford, M., Okeny, M., Bousfield, D., Mason, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Humans and Fish? Toxicological Sciences 108: 876, 2009.

Wise S.S., Mason M.D., Shaffiey F., Li Chen, T., Goodale, B., LaCerte, C., Craig, G., Walter, R., Payne, R., Kerr, I., Kraus, S. and Wise, Sr., J.P. Comparative Toxicity of Silver Nanoparticles in Human, Marine Mammal and Fish Cells. Toxicological Sciences 108:1223, 2009.

Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne, M., Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D. and Wise, Sr., J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity. Toxicological Sciences 108: 1793, 2009

Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond, D. and Wise, Sr., J.P. Arsenic Synergistically Increases Zinc Chromate-Induced Aneuploidy and Spindle Assembly Checkpoint Bypass in Human Lung Cells. Toxicological Sciences 108:1773, 2009.

Li Chen, T., Wise, S.S., Shaffiey F., Xie H., Holmes A.L., Kraus S.D. and Wise, Sr., J.P. Hexavalent Chromium Is More Clastogenic to Northern Right Whale Cells than Human Cells. Toxicological Sciences 108:1783, 2009.

LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Transformation in Human Bronchial Epithelial Cells. Toxicological Sciences 108:731, 2009.

Wise, Sr., J.P., Kraus, S., Payne, R., Wise, S.S., Kerr, I., LaCerte, C., Wise, J., Gianios, Jr, C., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Zhu, C. and O’Hara, T. Whales as Sentinels for Human Health: A Global Assessment of Chromium Pollution. Toxicological Sciences 108: 1221, 2009.

Wise, Sr., J.P, Holmes, A.L., Young, J.L., Savery, L.C., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C. and Xie, H. Hexavalent Chromium Induces Chromosome Instability by Disrupting Mitosis and Inducing Centrosome Amplification in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 103, 2009.

Wise, S.S., Holmes, A.L., Xie, H., Pelsue, S., Thompson, W.D. and Wise, Sr., J.P. Repetitive treatment of particulate chromate induces chromosome instability and a repair-deficient phenotype in human lung cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 103, 2009.

Xie H., LaCerte C. and Wise, Sr., J.P. A Potential Mechanism for Depleted Uranium-induced Carcinogenesis in Human Lung Epithelial Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 104, 2009.

Xie, H., LaCerte, C. and Wise, Sr., J.P. Depleted Uranium Has Genotoxic and Epigenetic Effects in Human Lung Epithelial Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 28, October, 2008.

LaCerte, C., Xie, H., and Wise, Sr. J.P. Depleted Uranium Induces Transformation in Human Bronchial Epithelial Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 17, October, 2008.

Li Chen, T., Wise, S.S., Shaffiey F., Xie H., Holmes A.L., Kraus S.D., and Wise, Sr. J.P. Hexavalent Chromium Is More Clastogenic to Northern Right Whale Cells than Human Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 6, October, 2008.

Wise, Jr. J.P., Wise, S.S., Wise, J., McKay, J., Courtemanche, A., Freedman, B., Browne, M.,Gianios, Jr. C., Mason, M., Shehata, T., Hammond, D., and Wise, Sr. J.P. Altered Gravity Exacerbates Chromate-Induced Genotoxicity. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 26, October, 2008.

Wise, J.T., LaCerte, C., Xie, H., Huang, J., McKay, J., Bickford, M., Okeny, M., Bousfield, D., Mason, M., and Wise, Sr. J.P. Are Cellulose Nanoparticles Toxic to Humans and Fish? Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 25, October, 2008.

Qin, Q., Xie, H., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T., and Wise, Sr. J.P. Particulate Chromate Induced DNA Double Strand Breaks Are Associated with XPF Gene Activity in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 23, October, 2008.

Young, J.L., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T., and Wise, Sr. J.P. Lunar Dust and its Components are Cytotoxic to Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October, p. 30, 2008.

Martino, J., Wise, Jr. J.P., Wise, J., Jeevarajan, A., Wallace, W., Hammond, D., Shehata, T., and Wise, Sr. J.P. Aluminum Is More Cytotoxic than Lunar Dust in Human Skin and Lung Fibroblasts. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 18, October, 2008.

Holmes, A.L., Buehler, D., Young, J., Wise, S.S., Jeevarajan, A., Wallace, W., Hammond, D., and Wise, Sr. J.P. Arsenic Potentiates Particulate Chromate-Induced Chromosome Instability. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 14, October, 2008.

Wise S.S., Mason M.D., Shaffiey F., Li Chen, T., Goodale, B., LaCerte, C., Craig, G., Walter, R., Payne, R., Kerr, I., Kraus, S., and Wise, Sr. J.P. Comparative Toxicity of Silver Nanoparticles in Human, Marine Mammal and Fish Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, p. 27, October, 2008.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr. J.P. Particulate Hexavalent Chromium Induces Centrosome Amplification Resulting in Chromosome Instability in Human Lung Cells. Proceedings of the Fifth Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2008.

Xie, H., LaCerte, C., and Wise, Sr. J.P. Carcinogenicity of Depleted Uranium in Human Lung Epithelial Cells. Proceedings of the Fifth Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2008.

Li Chen, T., Wise, S.S, Kraus, S., Shaffiey, F., Grau, M., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., and O’Hara, T., and Wise, Sr. J.P. Hexavalent Chromium May Be a Risk Factor for the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the Annual Meeting of the North Atlantic Chapter of the Society for Environmental Toxicology and Chemistry, June, 2008.

Martino, J., Li Chen, T., Wise, S.S., Shaffiey, F., Popa, O., Goertz, C.E.C., Kraus, S., Dunn, J.L., Gulland, F.M.D., Thompson, W.D., Zheng, T., and Wise, Sr., J.P. Cytotoxic and Genotoxic Effects of Chromium on Marine Mammal Lung Cells. Proceedings of the Annual Meeting of the North Atlantic Chapter of the Society for Environmental Toxicology and Chemistry, June, 2008.

Wise, S.S., Payne, R., LaCerte, C., Wise, J., Gianios, Jr., C., Perkins, C., Zheng, T., Zhu, C., Kerr, I., and Wise, Sr., J.P. Chromium in Sperm Whales: A Global Assessment. Proceedings of the International Association of Aquatic Animal Medicine Conference, 3, May, 2008.

Wise, Sr. J.P., Wise, S.S, Kraus, S., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., and O’Hara, T. Hexavalent Chromium May Threaten The Heath of the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the International Association of Aquatic Animal Medicine Conference, 2, May, 2008.

Wise, Jr., J.P., Xie, H., Wallace, W. Hammond, D., Jeevarajan, A. and Wise, Sr., J.P. Colonizing the Moon: A Study of the Toxic Effects of Lunar Dust on Human Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Shaffiey, F., Wise, S.S., Goertz, C.E.C., LaCerte, C., Dunn, J.L., Gulland, F.M.D.,Thompson W.D, Zheng T. and Wise, Sr., J.P. Cytotoxicity and Clastogenicity of Hexavalent Chromium in Steller Sea Lion Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani, H. and Wise, Sr., J.P. Medaka Cell Lines as Tools for Mechanistic Toxicity Studies. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Wise, J., LaCerte, C., Xie, H., Huang, J., Okeny, M. and Wise, Sr., J.P. Are Cellulose Nanoparticles Toxic to Humans? Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Wise S.S., Holmes A.L., Xie H., Pelsue S., Thompson W.D. and Wise, Sr. J.P. Repeated exposure to particulate chromate induces a repair- deficient phenotype and chromosome instability in human lung cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Holmes, A.L., Wise, S.S., Qin, Q., Young, J.L., Keierleber, J., Xie, H., Cavas, T., Schuler, J.H.C., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Thompson, W.D. and Wise, Sr., J.P. Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Li Chen, T., Martino, J., Wise, S.S., Holmes, A., Shaffiey, F., Popa, O., Goertz, C.E.C., Kraus, S., Dunn, J.L., Gulland, F.M., Thompson, W.D., Zheng, T. and Wise, Sr., J.P. Chromium-Contaminated Environments Are a Health Concern for Humans and Wildlife. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Qin Q, Wise, S.S, Michael D. Mason, D.M, Xie, H. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Gold Nanoparticles in Human Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Young, J.L., Holmes, A.L., Qin, Q., Xie, H. and Wise, Sr., J.P. Zinc Chromate Induces Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Martino, J., Li Chen, T., Wise, S., LaCerte, C., Keierleber, J., Kraus, S. and Wise, Sr., J.P. Zinc Chromate Cytotoxicity on Human and Right Whale Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

LaCerte, C., Xie, H. and Wise, Sr., J.P. Depleted Uranium Induces Neoplastic Transformation in Human Lung Epithelial Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Keierleber, J. Xie, H. and Wise, Sr., J.P. Cytotoxic and Genotoxic Effects of Zinc Chromate on Human Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Xie, H., Holmes, A.L., Joyce, K., Pelsue, S.R., Cavas, T., Young, J.L., Qin Q. and Wise, Sr., J.P. Particulate Chromium Induces Chromosome Damage and DNA Double Strand Breaks in Human Lung Cells. Presented at Making the Connection III: Toxics and Tomorrow’s Children Conference, March, 2008.

Wise, S.S., Holmes, A.L., Xie, H., Pelsue, S.R., Thompson, W.D. and Wise, Sr., J.P. Repeated exposure to particulate chromate induces a DNA double strand break repair-deficient phenotype and chromosome instability in human lung cells. Proceedings of the American Association for Cancer Research 49: 1873, 2008

Young, J.L., Holmes, A.L., Qin, Q., Xie, H., and Wise, Sr., J.P. Zinc Chromate Induces Spindle Assembly Checkpoint Bypass and Chromosome Instability in Human Lung Cells. Proceedings of the American Association for Cancer Research 49: 4729, 2008.

Holmes, A.L., Wise, S.S., Qin, Q., Young, J.L., Keierleber, J., Xie, H., Cavas, T., Schuler, J.H.C., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Thompson, W.D. and Wise, Sr., J.P. Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in Human Bronchial Cells. Proceedings of the American Association for Cancer Research 49: 4730, 2008.

Xie, H., Holmes, A.L., Joyce, K. Pelsue, S.R., Cavas, T., J Young, J.L., Qin, Q. and Wise, Sr., J.P. Zinc Chromate Induces Chromosome Instability and DNA Double Strand Breaks in Human Lung Cells. Proceedings of the American Association for Cancer Research 49: 4731, 2008.

Holmes, A.L., Qin, Q., Young, J.L., Joyce, K., Xie, H., Cavas, T. and Wise, Sr., J.P. Chronic Exposure to Zinc Chromate Induces Chromosome Instability in Human Lung Cells. Toxicological Sciences 102: 2093, 2008.

Goodale, B.C., Walter, R., Pelsue, S.R., Thompson, W.D., Wise, S.S., Winn, R.N., Mitani, H., Wise Sr., J.P. Medaka Cell Lines as Tools for Mechanistic Toxicity Studies. Proceedings of the Aquatic Models of Human Disease Conference, pp. 63-64 January, 2008.

Wise, S.S., Wise, Jr, J.P., Xie, H., Mason M.D., Craig, G., Payne, R., Kerr, I.A.R., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Silver Nanoparticles in Sperm Whale Cells. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 295, 2007.

Wise, Sr., J.P., Wise, S.S., Kraus, S., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., and O’Hara, T. The Cytotoxic and Genotoxic of Hexavalent Chromium In North Atlantic Right Whale (Eubalaena glacialis) Cells. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November. 2007.

Wise, S.S., Mason M.D., Holmes, A.L., Savery, L., Li Chen, T., Goodale, B., Shaffiey, F., Wise, Jr, J.P., Craig, G., Walter, R., Payne, R., Kerr, I., Spaulding, M., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human and Marine Cell Lines. Environmental and Molecular Mutagenesis. 48(7): 606, 2007.

Savery, L.C., Holmes, A.L., Sandwick, S.J., Xie, H., Wise, S.S., and Wise, Sr., J.P. Lead Chromate Induced Chromosome Instability and Decreased Expression of Key Spindle Assembly Checkpoint Proteins. Proceedings of the 7th International Chromosome Segregation and Aneuploidy Workshop, T33, 2007.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Environmental Carcinogens Induce Chromosome Instability through Centrosome Amplification in Human Lung Cells. Proceedings of the 7th International Chromosome Segregation and Aneuploidy Workshop, T36, 2007.

Wise, S.S., Lacerte, C., Wise, Jr., J.P.,  Kerr, I.A.R., Payne, R., Evers, D., and Wise, Sr., J.P. The Effects of Chromium Exposure and Its Toxicity in the Sperm Whale. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.

Wise, S.S., Mason, M.D., Shaffiey, F., Li Chen, T., Goodale, B., Craig, G., Walter, R., Payne, R., Kerr, I.A.R., Winn, R. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Silver Nanoparticles in Target Species. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.

Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., Kerr, I.A.R., Payne, R., and Wise, Sr., J.P. Genotoxicity of Mercury in the North Atlantic Right Whale (Eubalaena glacialis) and in the Sperm Whale (Physeter macrocephalus). Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.

Wise, S.S., Shaffiey, F., Lacerte, C., Payne, R., Kerr, I.A.R., Kraus, S., and Wise, Sr., J.P. The Effects of Chromium on Human, Sperm Whale and North Atlantic Right Whale Cells. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007

Xie, H., Wise, S.S., and Wise, Sr., J.P. Impaired Repair of Particulate Cr(VI)-induced DNA Double Strand Breaks Leading to Neoplastic Transformation. Toxicological Sciences 96: 1084, 2007.

Huang, S., Xie, H., Peng, C., Gupta, B.C., and Wise, Sr., J.P. Microarray Analysis of Particulate Chromate-Induced Gene Changes in Human Lung Cells. Toxicological Sciences 96: 1083, 2007.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe R.C., Thompson, L.H., Thacker, J., and Wise, Sr., J.P.  Rad51D, XRCC3, and Rad51C Play a Role in Repairing Chromate-Induced Chromosome Instability in Mammalian Cells by Homologous Recombination. Toxicological Sciences 96: 1082, 2007.

Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S., and Wise, Sr., J.P. Particulate Hexavalent Chromium Induces Chromosome Instability and Decreased Expression of Spindle Assembly Checkpoint Proteins. Toxicological Sciences 96: 635, 2007.

Xie, H., Wise, S.S., and Wise, Sr., J.P. MRE11 Protects Cells From DNA Double Strand Break-Induced Neoplastic Transformation. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 346, 2007.

Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., and Wise, Sr., J.P. Chemical Carcinogens Target the Centromere to Induce Chromosome Instability in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 344, 2007.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Centrosome Amplification is a Mechanism for Genomic Instability Induced by Environmental Carcinogens in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 161, 2007.

Wise, S.S., Throckmorton, H., Li Chen, T., Kraus, S., O’Hara, T., and Wise, Sr., J.P.  Cytotoxicity and Genotoxicity of Chromium and Mercury in Bowhead and North Atlantic Right Whale Cells. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November. 2006.

Bank, M.S., Crocker, J.B.  Wachtl, J. Kleeman, P., Currens, C., Fellers, G., May, J., Hothem, R., Wise, J., and  Madej, M.A.  2006.  Spatial Variation in Mercury Bioaccumulation, Energy Flow, and Trophic Complexity in Giant Salamanders from the Pacific Northwestern United States.  Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 345, 2006.

Wise, S.S., Goertz, C.E.C, Morin, A.T., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson, S., Thompson, W.D., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Chromium in Steller Sea Lion Lung, Skin and Testes Cells. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury and TBT in the Northern Atlantic Right Whale. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 316, 2006.

Wise, S.S., Lacerte, C., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D., and Wise, Sr., J.P. Chromium Exposure and Its Toxicity in the Sperm Whale. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena glacialis). Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Society of Environmental Toxicology and Chemistry (SETAC) Abstracts, p. 114, 2006.

Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury and TBT in the Northern Atlantic Right Whale. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Huang, S., Xie, H., Peng, C., Gupta, B.C., and Wise, Sr., J.P. Particulate Chromate-Induced Gene Changes in Microarrays. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Wise, S.S., Mason, M.D., Chada, V.G.R, LaCerte, C, Ng, A.K., and Wise, Sr., J.P. The Cytotoxicity of Gold Nanospheres in Human Lung Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Qin, Q., Wise, S.S., Oberdorster, G., Mason, M.D., Xie, H., and Wise, Sr., J.P. The Cytotoxicity of Copper Nanoparticles in Human Lung Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe R.C., Thompson, L.H., Thacker, J., and Wise, Sr., J.P. Homologous Recombination Repair Protects Against Chromate-induced Chromosome Instability in Chinese Hamster Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S., and Wise, Sr., J.P. Particulate Hexavalent Chromium Causes Chromosome Instability through Decreased Expression of Spindle Assembly Checkpoint Proteins. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Xie, H., Wise, S.S., and Wise, Sr., J.P.  Functional Role of MRE11 in the Repair of Particulate Cr(VI)-induced DNA Double Strand Breaks. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena glacialis). Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., Winn, R.N., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Medaka Cells and Interactions with Hypoxia. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Uygur, B., Wise, S.S., Mason, M.D., Ng, A.K., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Lead Chromate-Induced Chromosome Instability and Centrosome Amplification is Not Mediated by Lead. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Karaczyn, A.A., Xie, H, Cheng, R.Y.S., and Wise, Sr., J.P. In Vitro Toxicity and Neoplastic Transformation of Depleted Uranium: Effects on Human Bronchial Epithelial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Savery, L.C., Grlickova-Duzevik, E., Wise, S.S., Thompson, W.D., Hinz, J.M., Thompson, L.H., and Wise, Sr., J.P. Fancg Gene Protects Cells from Particulate Chromate-Induced Chromosome Instability. Proceedings of the EpA Graduate Fellowship Conference, September, 2006.

Xie, H., Wise, S.S., Deko, S., Katsifis, S., and Wise, Sr., J.P. Impaired Repair of Lead Chromate-Induced DNA Double Stand Break Leads To Neoplastic Transformation. Fourth Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Lead Chromate Induces Chromosome Instability via Centrosome Amplification and Spindle Assembly Checkpoint Bypass in Human Lung Cells. Fourth Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2006.

Bank, M.S., Crocker, J.B., Wachtl, J.L., Kleeman, P., Currens, C., Fellers, G., May, J., Hothem, R., Wise, J.P., Madej, M.A. Mercury Bioaccumulation in Pacific Giant Salamander Larvae from Lotic Ecosystems in the Pacific Northwestern United States. Presented at the Conference on Mercury as a Global Pollutant (Mercury 2006), Madison, Wisconsin, August, 2006

Lacerte, C., Wise, S.S., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D., and Wise, Sr., J.P. Chromium Exposure and Its Toxicity in the Sperm Whale. Proceedings of the North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry, June, 2006.

Throckmorton, H., Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury in Bowhead Whale (Balaena mysticetus) and Human Lung Cells. Proceedings of the North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry, June, 2006.

Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena glacialis). Proceedings of the North Atlantic Chapter of the Society or Environmental Toxicology and Chemistry, June, 2006.

Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Proceedings of the North Atlantic Chapter of the Society or Environmental Toxicology and Chemistry, June, 2006.

Wise, S.S., Kelly, R.S., Throckmorton, H., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. The Effect of Environmental Contaminants: Chromium, Mercury and Tributyltin, on Northern Atlantic Right Whale Cells. Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 37: 110, 2006.

Wise, S.S., Stackpole, M.M., Camrye, E., Duzevik, E.G., and Wise, Sr., J.P. Particulate Chromate-Induced Chromosome Instability Is Attenuated by Non-Homologous End Joining and Homologous Recombination Repair. Proceedings of the American Association for Cancer Research 47: 1087, 2006.

Savery, L.C., Wise, S.S., and Wise, Sr., J.P. Lead Chromate Induces DNA-DNA Crosslinks Leading to Chromosome Damage. Proceedings of the American Association for Cancer Research 47: 1084, 2006.

Xie, H, Wise, S.S., Deko, S., Katsifis, S., and Wise, Sr., J.P. Functional Role of MRE11 in the Repair of Particulate Chromium (VI)- Induced DNA Double Strand Breaks. Proceedings of the American Association for Cancer Research 47: 1086, 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Lead Chromate-Induced Chromosome Instability is Caused by Centrosome Amplification in Human Lung Cells. Proceedings of the American Association for Cancer Research 47: 1088, 2006.

Karaczyn, A.A., Xie, H., and Wise, Sr., J.P. Depleted Uranium Induced Malignant Transformation in Human Lung Epithelial Cells. Proceedings of the American Association for Cancer Research 47: 5215, 2006.

Duzevik, E.G., Wise, S.S., Munroe, R.C., and Wise, Sr., J.P. XRCC1 Is Involved in Repair of Lead Chromate-Induced Chromosome Damage. Proceedings of the American Association for Cancer Research 47: 1072, 2006.

Knight, T., Wise, S.S., Wise, Sr., J.P., and Ng, A.K. Immunological and Toxic Effects of Gold Nanoparticles. Presented at the workshop: Overcoming Obstacles to Effective Research Design in Nanotoxicology, April, 2006.

Wise, S.S., Pfefferle, L., Goodale, B., Bresler, A., Ng, A., and Wise, Sr., J.P. The Genotoxicity of Carbon Single-Walled Nanotubes in Human Bronchial Cells. Presented at the workshop: Overcoming Obstacles to Effective Research Depresesign in Nanotoxicology, April, 2006.

Wise, S.S., Holmes, A., Xie, H., Mason, M.D., Chada, V.G.R., Goodale, B., Shaffiey, F., LaCerte, C., Qin, Q., Ng., A.K. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Gold Nanospheres in Human Lung Cells. Presented at the workshop: Overcoming Obstacles to Effective Research Design in Nanotoxicology, April, 2006.

Wise, S.S., Kirstein, D., Romano, T., and Wise, Sr., J.P. The National Marine Cell Line Library. Proceedings of the annual meeting of the Northeast Regional Stranding Network, March, 2006.

Wise, Sr., J.P. Sperm Whales: Are They Exposed to Dangerous Levels of Metals and Are They Sentinels for Human Health? A Case Study of the Toxic Effects of Chromium. Proceedings of the Consultative Group on Biological Diversity’s Annual Marine Working Group, March, 2006.

Savery, L.C., Wise, S.S., and Wise, Sr., J.P. Particulate Chromium Induced DNA-DNA Crosslinks Lead to Chromosome Damage. Toxicological Sciences 90: 545, 2006.

Xie, H, Deko, S., Wise, S.S., Katsifis, S., and Wise, Sr., J.P. ATM and MRE11 Are Involved in the Repair of Particulate Chromium (VI)- Induced DNA Double Strand Breaks. Toxicological Sciences 90: 544, 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Amplification and Aneuploidy in Human Lung Cells. Toxicological Sciences 90: 519, 2006.

Wise, S.S., Pfefferle, L., Goodale, B., Bresler, A., Ng, A., and Wise, Sr., J.P. The Genotoxicity of Carbon Single-Walled Nanotubes in Human Bronchial Cells. Proceedings of the international symposium: Nanotoxicology Biomedical Aspects, January, 2006.

2001-2005

Wise, S.S., Kelly, R.S., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. The Effect of Environmental Contaminants; Chromium, Mercury and Tributyltin, on Bowhead and Northern Atlantic Right Whale Cells. Proceedings of the biennial meeting of Society for Marine Mammalogy, December, 2005.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. Clonogenic Toxicity of Benzo [a]pyrene Is Higher in Reproductive Tissue than in Somatic Tissues of the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the biennial meeting of Society for Marine Mammalogy, December, 2005.

Wise, S.S., Kelly, R.S., Kirstein, D.P., Romano, T., and Wise, Sr., J.P. The National Marine Cell Line Library Repository. Proceedings of the International Environmental Specimen Bank Symposium, November, 2005.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. The Cytotoxicity of Benzo[a] pyrene in Reproductive and Somatic Cells from the Northern Right Whale (Eubalaena glacialis). Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November, 2005.

Wise, S.S., Kelly, R.S., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. Tributyltin and Hexavalent Chromium Are Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the North Atlantic Right Whale Consortium, November, 2005.

Kelly, R.S., Wise, S.S., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. Establishment and Immortalization of Whale Cell Lines. Proceedings of the North Atlantic Right Whale Consortium, November, 2005.

Wise, S.S., Stackpole, M.M., Camyre, E., Duzevik, E.G., and Wise, Sr., J.P. Non-Homologous End Joining and Homologous Recombination Repair Protect Against Particulate Chromate-Induced Chromosome Instability. Proceedings of the International Conference on Environmental Mutagens and the Annual Meeting of the Environmental Mutagenesis Society, Mutation Research, 577 (1-2): 413, 2005.

Wise, S.S., Morin, A.T., Goertz, C.E.C., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Metal Toxicity of Sodium Chromate in Steller Sea Lion Bronchus and Dermis Compared To Humans. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), June, 2005.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. Benzo[a]pyrene Cytotoxicity in Right Whale (Eubalaena Glacialis) Skin, Testis and Lung Cell Lines. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), June, 2005.

Savery, L.C., Wise, S.S., and Wise, Sr., J.P. Particulate Chromate-Induced DNA-DNA Crosslinks Do Not Lead to Chromosome Damage. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Kelly, R., Holmes, A.L., Wise, S.S., Morin, A.T., Goertz, C.E.C., Atkinson, S., Dunn, J.L., Gulland, F.M.D., and Wise, Sr., J.P. Sodium Chromate Toxicity in Steller Sea Lion Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Duzevik, E.G., Wise, S.S., Munroe, R.C., and Wise, Sr., J.P. Repair of Chromate-Induced Chromosome Damage Is Mediated by XRCC1. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Xie, H., Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Mechanisms of Repair of Particulate Cr(VI)-Induced DNA Double Strand Breaks. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Wise, S.S., Holmes, A.L., Sandwick, S.J., and Wise, Sr., J.P. Lead Chromate-Induced Centromeric Abnormalities in Human Lung Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in Human Lung Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Holmes, A.L., Wise, S.S., Morin, A.T., Goertz, C.E.C, Atkinson, S., Dunn, J.L., Gulland, F.M.D., and Wise, Sr., J.P. Sodium Chromate Toxicity in Steller Sea Lion Cells. Proceedings of the Annual Meeting of the North Atlantic Chapter of the Society for Environmental Toxicology and Chemistry, June, 2005.

Wise, S.S., Holmes, A.L., Sandwick, S.J., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Induces Premature Anaphase and Inhibits Repair of Chromosome Damage in Human Lung Cells. Proceeding of the American Thoracic Society, 2:A744, 2005.

Xie, H., Wise, S.S., and Wise, Sr., J.P. MRE11 Mediated Repair of Lead Chromate Induced DNA Double-Strand Breaks. Proceedings of the American Association for Cancer Research 46:3064, 2005.

Wise, S.S., Holmes, A.L., Sandwick, S.J., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Lead Ions Interfere with Repair of Particulate Chromate-induced Chromosome Aberrations Resulting in Prolonged Chromosome Instability in Human Lung Cells. Proceedings of the American Association for Cancer Research 46:3043, 2005.

Xie, H., Wise, S.S., and Wise, Sr., J.P. ATM Mediated Repair of Lead Chromate Induced DNA Double-Strand Breaks Prevents Genomic Instability in Human Lung Cells. Proceedings of the Keystone Symposia on DNA Repair, 243, 2005.

Lynch, J.P., Wise, S.S., and Wise, Sr., J.P. Arsenic Induces Chromosomal and Centromeric Abnormalities in Human Lung Cells. Toxicological Sciences 84(S-1):145, 2005.

Wise, S.S., Holmes, A.L., Moreland, J.A., and Wise, Sr., J. P. Genotoxicity of Particulate Uranium and Chromium. Toxicological Sciences 84(S-1):160, 2005.

Holmes, A.L., Sandwick, S.J., Wise, S.S., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Chronic Exposure to Lead Ions from Lead Chromate Interferes with Normal Mitotic Progression. Toxicological Sciences 84(S-1):1145, 2005.

Xie, H., Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks and Activates ATM Kinase in Human Lung Cells. Toxicological Sciences 84(S-1):1134, 2005.

Duzevik, E.G., Wise, S.S., Munroe, R.C., and Wise, Sr., J.P. Repair of Chromate-Induced Chromosome Damage Is Mediated by XRCC1. Toxicological Sciences 84(S-1):1135, 2005.

Van Epps, G., Langley-Turnbaugh, S., Gordon, N.R., and Wise, J.P. The Relationship between Maine Soil and PM10. Proceedings of the International Soil Science Meeting, December 2004.

Wise, S.S., Stackpole, M.M., Duzevik, E.G., Munroe, R.C., Thompson, L.H., and Wise, Sr., J.P. Homologous Recombination Protects against Particulate Chromate-Induced Genomic Instability in Chinese Hamster Cells. Proceedings of the ASM Special Conference: DNA Repair and Mutagenesis: from Molecular Structure to Biological Consequences, November, 2004.

Bank, M.S., Driscoll, C., Fernandez, I., Wise, J., Amirbahman, A., and Foster, D. Effects of Disturbance Regimes on Mercury Bioaccumulation in Two-Lined Salamanders from Stream Ecosystems in the Northeastern United States. Proceedings of the Annual Meeting of the Northeast Resource Council, November 2004.

Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. The Effect of Environmental Contaminants on Northern Atlantic Right Whale and Bowhead Whale Cell Cultures. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November 2004.

Kelly, R., Wise, S.S., Kraus, S., O’Hara, T., Romano, T, and Wise, Sr., J.P. Development of Right Whale and Bowhead Whale Cell Lines. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November 2004.

Van Epps, G., Jalbert, A., Alley, D., Langley-Turnbaugh, S., Gordon, N.R., and Wise, Sr., J.P. Metal Composition of Maine Particulate Matter (PM) and Effects of These Metals on Human Lung Fibroblasts. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Xie, H., Wise, S.S., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Sandwick, S.J., Holmes, A.L., Wise, S.S., Gordon, N., and Wise, Sr., J.P. Lead Ions Disrupt Normal Mitotic Progression in Human Lung Cells after More Chronic Exposures to Lead Chromate. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Duzevik, E.G., Munroe, R.C., Wise, S.S., and Wise, Sr., J.P. XRCC1 Is Involved in Repair of Lead Chromate-Induced Chromosome Damage. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C., Thompson, L.H., and Wise, Sr., J.P. Particulate Chromate-Induced Genomic Instability Is Prevented by Homologous Recombination. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Chason, J., Bodoky, A., Xie, H., Wise, S.S., Holmes, A.L., Teufack, S., Katsifis, S., and Wise, Sr., J.P. The Functional Role of NBS1 in the Repair of Cr(VI)-Induced DNA Damage. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Lynch, J.P., Wise, S.S., and Wise, Sr., J.P. Arsenic Induces Centromeric Abnormalities and Endoreduplication in Chromosomes of Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F.M.D., Morin, A., Jayasundra, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Sodium Chromate Toxicity and Uptake in Steller Sea Lion Cells. Proceedings of the 22nd Wakefield Fisheries Symposium: Sea Lions of the World Conservation and Research in the 21st Century, September, 2004.

Xie, H., Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces Double-Strand Breaks in Human Lung Cells. Proceedings of the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. September, 2004.

Wise, S.S., Holmes, A.L., Xie, H., Gordon, N., Moreland, J.A., Sandwick, S.J., Stackpole, M.M., Fomchenko, E., Teufack, S., May, Jr., A.J., Katsifis, S.P., Thompson, W.D., and Wise, Sr., J.P. Mechanisms of Particulate Chromate-Induced Genotoxicity. Proceedings of the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. September, 2004.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Bozza, M., Atkinson, S., Gulland, F.M.D., Taylor, R.J., and Wise, Sr., J.P. In Vitro Metal Toxicity in Steller Sea Lion (Eumetopias jubatus) Fibroblasts with an Emphasis on Hexavalent Chromium. Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 35: 74-75 2004.

Xie, H., Moreland, J.A., Wise, S.S., and Wise, Sr., J.P. Particulate Hexavalent Chromium Induces DNA Double Strand Breaks in Human Bronchial Cells. Proceedings of the American Association for Cancer Research, 45: LB-168, 2004.

Wise, S.S., Holmes, A.L., Xie, H., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Lead Chromate-Induced Cytotoxicity In Human Bronchial Cells Is Mediated By Extracellular Chromium and Does Not Require Functional p53 or Rb. Proceedings of the American Association for Cancer Research, 45: LB- 180, 2004.

Zhang, Y, Wise, Sr., J.P., Holford, T.R., Xie, H., Boyle, P., Zahm, S.H., Zhang B., Zou, K.Y., Owens, P.H., and Zheng, T. Polychlorinated Biphenyls, Cytochrome P4501A1 Polymorphism, and Risk of Breast Cancer in Connecticut Women. Proceedings of the American Association for Cancer Research, 45: 3729, 2004.

Jalbert, A., Gordon, N., Langley-Turnbaugh, S., and Wise, Sr., J.P. The Effect of Urban Particulate Matter on Human Lung Cells. Toxicological Sciences 67(S): 1039, 2004.

Xie, H., Holmes, A.L., Wise, S.S., Gordon, N., and Wise, Sr., J.P. Particulate Hexavalent Chromium-Induced Clastogenesis is Mediated by Extracellular Dissolution that Does Not Require Particle Cell Contact. Toxicological Sciences 67(S): 281, 2004.

Wise, S.S., Holmes, A.L., Thompson, M., Smith, B.E., O’Hara, T., and Wise, Sr., J.P. Comparative Chromium Toxicity in Cultured Bowhead Whale and Human Lung Cells. Toxicological Sciences 67(S): 759, 2004.

Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Lead Chromate (LC) Induces Cell Cycle Arrest in WTHBF-6 Cells, However Lead Alone Is Mitogenic. Toxicological Sciences 67(S): 270, 2004.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Morin, A., Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Cytotoxicity of Two Heavy Metals in Steller Sea Lion Dermal, Renal, Bronchial, and Testicular Cells. Toxicological Sciences 67(S): 756, 2004.

Diaz, W.C., Wise, S.S., and Wise, Sr., J.P. Uranium is Cytotoxic and Genotoxic to Human Lung Cells. Toxicological Sciences 67(S): 272, 2004.

Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Sodium Chromate Toxicity in Bronchus and Dermis of Steller Sea Lions and Humans. Toxicological Sciences 67(S): 757, 2004.

Holmes, A.L., Gordon, N., and Wise, Sr., J.P. Lead Chromate-Induced Cytotoxicity in Human Bronchial Cells is Mediated by Extracellular Chromium. Toxicological Sciences 67(S): 760, 2004.

Wise, S.S., Holmes, A.L., Xie, H., and Wise, Sr., J.P. The Physico-Chemical Mechanisms of Particulate Chromium (VI)-Induced Clastogenesis. Proceedings of the AACR Special Conference in Radiation Biology and Cancer, February 2004.

Xie, H., Wise, S.S., Holmes, A., Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Particle Dissolution Is Necessary for Lead Chromate- Induced Genotoxicity in Human Bronchial Cells. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Holmes, A.L., Gordon, N., and Wise, Sr., J.P. Chromium Ions Are the Proximate Clastogenic Species for Particulate Hexavalent Chromium in Human Lung Cells. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Comparative Cytotoxicity of Hexavalent Chromium Compounds in Humans and Steller Sea Lions. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Diaz, W.C., Wise, S.S., and Wise, Sr., J.P. The Cytotoxicity of Depleted Uranium in Human Bronchial Cells. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Wise, S.S., Goertz, C.E.C., Thompson, M., Smith, B., O’Hara, T., St. Aubin, D.K., and Dunn, J.L., and Wise, Sr., J.P. The Effects of Environmental Contaminants on Balaenidae Whales (Balaena mysticetus and Eubalaena glacialis): Metal Toxicity in Bowhead Whales. Proceedings of the Annual Meeting of the Society of Marine Mammalogy, December 2003.

Goertz, C.E.C., Wise, S.S., Jayasundara, N., St. Aubin, D.K., Dunn, J.L., Bozza, M., Atkinson, S., Gulland, F, and Wise, Sr., J.P. Metal Toxicity in Cultured Steller Sea Lion Fibroblasts. Proceedings of the Annual Meeting of the Society of Marine Mammalogy, December 2003.

Wise, Sr., J.P., Wise, S.S., Goertz, C.E.C., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S., and Gulland, F. Toxicity of Heavy Metals in Cultured Steller Sea Lion Cells. Proceedings of the Society of Environmental Toxicology and Chemistry, November, 2003.

Xie, H., Holmes, A.L., Wise, S.S., Gordon, N., and Wise, Sr., J.P. Lead Chromate Releases Extracellular Cr Ions That Produce Its Clastogenic Effects. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Wise, S.S., Holmes, A.L., Thompson, M., Smith, B.E., O’Hara, T., and Wise, Sr., J.P. Cytotoxicity of Particulate and Soluble Hexavalent Chromium in Bowhead Whale and Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Particulate Hexavalent Chromium-Induced Cell Cycle Arrest Is Mediated by Cr Ions. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F., Morin, A.T., Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Sodium Chromate and Cadmium Chloride Toxicity in Steller Sea Lion Dermal, Renal, Bronchial, and Testicular Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Diaz, W.C., Wise, S.S., and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Depleted Uranium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F., Jayasundara, N., Bozza, M, Atkinson, S., and Wise, Sr., J.P. Comparative Cytotoxicity of Hexavalent Chromium in Humans and Steller Sea Lions. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Wise, Sr., J.P., Wise, S.S., Goertz, C.E.C., Thompson, M., Smith, B., O’Hara, T., St. Aubin, D.K., and Dunn, J.L. Comparative Chemical Carcinogenesis of Environmental Contaminants in Balaenidae Whales (Balaena mysticetus and Eubalaena glacialis) and Humans: Bowhead Whales Are Resistant to Hexavalent Chromium. Proceedings of the Aquatic Animal Models of Human Disease Conference, September 30, 2003.

Wise, S.S., Goertz, C.E.C., Little, J.E., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S., Gulland, F., and Wise, Sr., J.P. Metal Toxicity in Cultured Steller Sea Lion Fibroblasts. Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 35: 140, 2003.

Holmes, A.L., Goertz, C.E.C., Wise, S.S., Little, J.E., Moreland, J.A., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S., Gulland, F., and Wise, Sr., J.P. Cell Culture and Toxicology of Marine Mammals. Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.

Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Particle Dissolution Is Necessary for Lead Chromate-Induced Genotoxicity in Human Bronchial Cells. Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.

Lynch, J.P, Little, J.E., Wise, S.S., Slotnick, M.J, and Wise, Sr., J.P. Comparative Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., and Wise, Sr., J.P. Cell Culture, Toxicology, and Stranded Marine Mammals. Proceedings of the Northeast Region Stranding Network, April, 2003.

Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell Cycle Arrest Is Concentration Dependent. Proceedings of the Maine Biotechnology Association Annual Meeting, April, 2003.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., and Wise, Sr., J.P. Cell Culture, Toxicology, and Stranded Marine Mammals. Proceedings of the Maine Biotechnology Association Annual Meeting, April, 2003.

Xie, H, Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Lead Chromate Genotoxicity Is Mediated by Particle Dissolution and Not Particle Internalization. Toxicological Sciences 72(S):217, 2003.

Little, J.E., Wise, S.S., Slotnick, M.J, and Wise, Sr., J.P. Cytotoxicity and Clastogenicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Toxicological Sciences 72(S):219, 2003.

Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell Cycle Arrest Is Concentration Dependent. Toxicological Sciences 72(S):218, 2003.

Shuler, J.H.C., Wise, S.S., Katsifis, S., and Wise, Sr., J.P. Barium Chromate is Cytotoxic and Clastogenic to Human Bronchial Cells. Toxicological Sciences 72(S):218, 2003.

Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S., and Wise, Sr., J.P. Chromium Is the Proximate Genotoxic Species in Lead Chromate-Induced Clastogenicity in Human Bronchial Cells. Toxicological Sciences 72(S):217, 2003.

Holmes, A.L., Wise, S.S., Ketterer, ME, Xie, H, Hartsock, W, Shuler, J., Katsifis, S., and Wise, Sr., J.P. Comparative Genotoxicity of Two Particulate Hexavalent Chromium Compounds in Human Bronchial Cells. Toxicological Sciences 72(S):218, 2003.

Wise, Sr., J.P., Holmes, A. L., Wise, S.S., Little, J.A., Xie, H., Bozza, M., Moreland, St. Aubin, D.K., Dunn, J.L., Atkinson, S., Gulland, F., and Bursian, S. Hexavalent Chromium Cytotoxicity Is Organ and Species Specific for Steller Sea Lion and Mink Cells. Proceedings of the EVOS- GEMS/GLOBE /NMFS Steller Sea Lion Research Symposium, January 2003.

Wise, S.S., Elmore, L.W., Holt, S.E., Little, J.E., Bryant, B.H., and Wise, Sr., J. P. Ectopic Expression of hTERT in Human Bronchial Cells Extends Cellular Lifespan without Affecting Hexavalent Chromium-Induced Cytotoxicity or Genotoxicity. Proceedings of the American Association for Cancer Research Conference on the Role of Telomeres and Telomerase in Cancer, December, 2002.

Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Lead Chromate-Induced Genotoxicity Is Mediated by Chromium and Not Lead in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Particle Dissolution Is Necessary For Lead Chromate-Induced Genotoxicity in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Lynch, J.P, Little, J.E., Wise, S.S., Slotnick, M.J., and Wise, Sr., J.P. Comparative Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Lead Chromate-Induced Cell Cycle Arrest Progresses From G1 to S-Phase Arrest With Increasing Concentrations. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Shuler, J.H.C., Wise, S.S., Katsifis, S.P., and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Barium Chromate in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Holmes, A.L., Wise, S.S., Ketterer, M.E., Xie, H., Hartsock, W.J., Shuler, J.H.C., Katsifis, S.P., and Wise, Sr., J.P. Barium Chromate Is More Potent Than Lead Chromate in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Little, J.E., Bryant, B.H., and Wise, Sr., J. P. Establishing a New Lung Cell Culture Model for Studying Carcinogenic Metals. Proceedings of the 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, September, 2002

Wise, Sr., J.P., Antonucci, P.G., Holt, S.E., Elmore, L.W., Forrest, Jr., J.N., Boyer, J., and Bryant, B.H. Establishing Cell Lines In Four Marine Species: Bowhead Whale, (Balaena mysticetus), Beluga Whale (Delphinapterus leucas), Little Skate (Raja erinacea), and Spiny Dogfish (Squalus acanthias). The Bulletin 41:48-49, 2002.

Barnes, D.W., Forrest Jr, J.N., Wise, Sr., J.P., and Winn, R.N. Derivation of Continuous Marine Cell Lines for Model Systems in Toxicology and Cell Biology. The Bulletin, 41:45-47, 2002.

Little, J.E., Wise, S.S., and Wise, Sr., J.P. The Genotoxicity of Particulate and Soluble Hexavalent Chromium in Human Bronchial Cells. Toxicological Sciences 66(S):32 (LB16), 2002.

Antonucci, P.G., Wise, S.S., Pincavage, A., Singh, N.P., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Cr(VI) in Human Bronchial Cells. Toxicological Sciences 66(S):32 (152), 2002.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H., and Wise, Sr., J.P. A New Human Bronchial Cell Culture Model for Investigating Metal-Induced Lung Carcinogenesis. Toxicological Sciences 66(S):32 (151), 2002.

Bidulescu, A, Wise, S.S., May, A., Tang, E.R., Bryant, B.H., Schumm, K.R., and Wise Sr., J.P. Hexavalent Chromium Toxicity in Human Lung Cells, Chinese Hamster Ovary Cells and A549 Cells: Current Cell Culture Models Are Inadequate. Toxicological Sciences 66(S):32 (150), 2002.

Wise, Sr., J.P., Antonucci, P.G., and Bryant, B.H. Toxicology of Hexavalent Chromium in Five Marine Animals: Bowhead Whale, (Balaena mysticetus), Beluga Whale (Delphinapterus leucas), Little Skate (Raja erinacea), Spiny Dogfish (Squalus acanthias) and the Killifish (Fundulus heteroclitus). The Bulletin 40:29-30, 2001.

Wise, S.S., and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Particulate and Soluble Hexavalent Chromium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2001.

Bidulescu, A, Wise, S.S., May, A., Tang, E.R., Bryant, B.H., Schumm, K.R., and Wise, Sr., J.P. A Comparison of Chromium Toxicity in Three Cell Culture Models. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2001.

Wise, Sr., J.P., Wise, S.S. and St. Aubin, D.J. Establishing Cultures of Bronchial Cells from the Common Dolphin (Delphinus delphis). Society of Environmental Chemistry and Toxicology (SETAC) Abstracts p. 158, 2001.

Wise, Sr., J.P., Wise, S.S. and St. Aubin, D.J. Establishing Continuous Cell Lines in Three Marine Species Delphinus delphius, Tursiops truncatus, and Delphinapterus leucas. Proceedings of the Mount Desert Island Biological Laboratory Meeting on Marine Models, May 2001.

Wise, Sr., J.P., Wise, S.S., Elmore, L.W., Antonucci, P.G., and Holt, S.E. Establishing Continuous Human Cell Lines with hTERT. Proceedings of the Mount Desert Island Biological Laboratory Meeting on Marine Models, May 2001.

Wise, S.S., Ketterer, M.E., Antonucci, P.G., and Wise, Sr., J.P. Genotoxic Effects of Particulate and Soluble Cr(VI) in a Human Bronchial Cell Culture Model. Environmental Molecular Mutagenesis, 37:80, 2001.

1996-2000

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H., and Wise, Sr., J. P. Establishing a Human Bronchial Cell Culture Model for Lung Carcinogens. Proceedings of the American College of Toxicology Annual Meeting, November 2000.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H., and Wise, Sr., J.P. A Human Bronchial Cell Model for Lung Carcinogens. Proceedings of the Northeast Society of Toxicology Meeting, October 2000.

Rabinowitz, P.M., Wise, Sr., J.P., Antonucci, P.G., and Mobo, B.H. Glutathione-S-Transferase M1 (GSTM1) and T1(GSTT1) as Predictors of Susceptibility to High Frequency Hearing Changes in Noise-Exposed Workers. Proceedings of the Environmental Carcinogenesis Population Risk and Genetic Susceptibility Meeting, October, 2000.

May, Jr., A.J., Wise, S.S., Stearns, D.M., Ketterer, M.E., and Wise, Sr., J.P. Differential Effects of Particulate and Soluble Hexavalent Chromium on the Cell Cycle. Proceedings of the American Association for Cancer Research Conference on the Genetic and Functional Consequences of Cell Cycle Alteration in Cancer, October 1999.

May, Jr., A.J., Wise, S.S., Stearns, D.M., Ketterer, M.E., Wise, Sr., J.P. Particulate Hexavalent Chromium and Human Health in The Arctic. Proceedings of the American Association for the Advancement of Science Meeting, September 1999.

Hussain, S.P., Amstad, P., Ambs, S., Bennett, W.P., Wise, Sr., J.P., Harrington, A., Shields, P.G., and Harris, C.C. P53 Mutation Load Is Increased in Ulcerative Colitis, a Cancer-Prone Disease. Proceedings of the American Association for Cancer Research, 37:963, 1996.

Wise, Sr., J.P., Caporasso, N.E., Trivers, G.E., Tucker, M.A., Trump, B.F., Harris, C.C., and Shields, P.G. The relationship of Glutathione-S-Transferase Theta (GST-T) Polymorphism to Lung Cancer Risk. Proceedings of the American Association for Cancer Research, 37: 1784, 1996.

Wise, Sr., J.P., Caporasso, N.E., Trivers, G.E., Tucker, M.A., Trump, B.F., Harris, C.C., and Shields, P.G. Glutathione-S-Transferase Theta (GST-T) and Lung Cancer Risk. Proceedings of the American Association for Cancer Research Conference on Cancer Susceptibility Genes and Molecular Carcinogenesis Meeting, February 1996.

1991-1995

Blankenship, L.J., Wise, J.P., Orenstein, J.M., and Patierno, S.R. Vitamin Pretreatment Protects Cells from Chromium-Induced Apoptosis without Decreasing Chromium-Induced DNA Adducts. Proceedings of the American Association for Cancer Research 36: 68, 1995.

Stearns, D.M., Wise, Sr., J.P., Patierno, S.R., and Wetterhahn, K.E. The Dietary Supplement Chromium Picolinate Induces Chromosome Damage in Chinese Hamster Ovary Cells. The FASEB Journal Abstracts 9(3): A451, 1995.

Wise, J.P., Orenstein, J.M., and Patierno, S.R. Inhibition of Lead Chromate Clastogenesis by Ascorbate: Relationship to Particle Dissolution and Uptake. Proceedings of the American Association for Cancer Research 34: 3316, 1993.

Manning, FC.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C., and Patierno, S.R. Induction of Apoptosis by Carcinogenic Chromate: Relationship to Genotoxicity, Cell Cycle Delay, and Inhibition of Macromolecular Synthesis. Proceedings, Second International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogenicity, 1993.

Wise, J.P., Xu, J., and Patierno, S.R. Relationship of Chromate-Induced DNA Damage to Chromosomal Aberrations. The Toxicologist 12: 1201, 1992.

Wise, J.P., Leonard, J.C., and Patierno, S.R. Clastogenesis of Lead Chromate (PbCrO4) Particles in Hamster and Human Cells. Proceedings of the American Association for Cancer Research 32: 635, 1991.

Patierno, S.R., Dirscherl, L., and Wise, J.P. Mitogenesis and Clastogenesis of Particulate Metal Carcinogens in Respiratory Epithelial Cells. The FASEB Journal Abstracts 5: 7156, 1991.