Department of Chemistry

Peter Woodruff

Associate Professor of Chemistry

Office Location

C386A Science building

Faculty Office Hours Spring 2021

M 2:00-3:00, Tu 10:00-11:00, Th 3:00-4:00, or by appointment

Phone

(207)780-4736

Academic Degrees

  • Ph.D, Molecular and Cellular Biology, University of California, Berkeley, 2007
  • B.A., Biophysical Chemistry, Dartmouth College, 1999

Research Interests

  • Bioremediation of chromate
  • Biochemistry of the mycobacterial cell wall
  • Synthesis of trehalose analogs

Recent Publications

Kalera, K., Stothard, A.I., Woodruff, P.J., and B.M. Swarts. “The role of chemoenzymatic synthesis in advancing trehalose analogues as tools for combatting bacterial pathogens.” Chem Commun. 2020 Oct 1;56(78):11528-11547


Danielson, N.D., Collins, J., Stothard, A.I., Dong, Q.Q., Kalera, K., Woodruff, P.J., DeBosch, B.J., Britton, R.A., and B.M. Swarts. “Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.” Chem Commun. 2019 Apr 23;55(34):5009-5012.


Peña-Zalbidea, S., Huang, A.Y., Kavunja, H.W., Salinas B, Desco, M., Drake, C., Woodruff, P.J., Vaquero, J.J., and B.M. Swarts. “Chemoenzymatic radiosynthesis of 2-deoxy-2-[18F]fluoro-d-trehalose ([18F]-2-FDTre): A PET radioprobe for in vivo tracing of trehalose metabolism.”Carbohydr Res. 2019 Jan 15;472:16-22. 

 

Groenevelt, J.M., Meints, L.M., Stothard, A.I., Poston, A.W., Fiolek, T.J., Finocchietti, D.H., Mulholand, V.M., Woodruff, P.J., and B.M. Swarts. “Chemoenzymatic Synthesis of Trehalosamine, an Aminoglycoside Antibiotic and Precursor to Mycobacterial Imaging Probes.” J Org Chem. 2018 Aug 3;83(15):8662-8667. 


Swarts, B.M. and P.J Woodruff. “Chemoenzymatic Synthesis of Trehalose Analogs.” U.S. patent # 9,873,905. Filed March 6, 2015 and issued January 23rd, 2018


Wolber, J.M., Urbanek, B.L., Meints, L.M., Piligian, B.F., Lopez-Casillas, I.C., Zochowski, K.M., Woodruff, P.J., and  B.M. Swarts. “The trehalose-specific transporter LpqY-SugABC is required for antimicrobial and anti-biofilm activity of trehalose analogues in Mycobacterium smegmatis.” Carbohydr Res. 2017 Oct 10;450:60-66. 


O'Neill, M.K., Piligian, B.F., Olson, C.D., Woodruff, P.J., and B.M. Swarts. “Tailoring Trehalose for Biomedical and Biotechnological Applications.” Pure Appl Chem. 2017 Sep;89(9):1223-1249. 


Meints, L.M., Poston, A.W., Piligian, B.F., Olson, C.D., Badger, K.S., Woodruff, P.J., and B.M. Swarts. “Rapid One-Step Enzymatic Synthesis and All-Aqueous Purification of Trehalose Analogues.”  J Vis Exp. 2017 Feb 17;(120).


Rundell, S.R., Wagar, Z.L., Meints, L.M., Olson, C.D., O'Neill, M.K., Piligian, B.F., Poston, A.W., Hood, R.J., Woodruff, P.J., and B.M. Swarts. “Deoxyfluoro-D-trehalose (FDTre) analogues as potential PET probes for imaging mycobacterial infection.” Org Biomol Chem. 2016 Sep 28;14(36):8598-609.


Urbanek, B.L., Wing, D.D., Haislop, K.S., Hamel, C, Kalscheuer, R., Woodruff, P.J., and B.M. Swarts. “Chemoenzymatic Synthesis of Trehalose Analogues: Rapid Access to Probes for Investigating Mycobacteria.” Chembiochem. 2014 Sep 22;15(14): 2066-70

Frederick, T.M., Taylor, E.A., Willis, J.L., Shultz, M.S., and P.J. Woodruff, “Chromate reduction is expedited by bacteria engineered to produce the compatible solute trehalose”, Biotechnology Letters, 35, 1291-1296, (2013)


Frederick, T.M. and P.J. Woodruff.  “Bacteria with increased trehalose production and method for using the same in bioremediation.” U.S. patent # 8,481,026. Filed April 16, 2010 and issued July 13, 2013


Woodruff  P.J., Carlson B.L., Siridechadilok B., Pratt M.R., Senaratne R.H., Mougous J.D., Riley L.W., Williams S.J., and C.R. Bertozzi. “Trehalose is required for the growth of Mycobacterium smegmatis.” J. Biol Chem., 279(28) 28835-43, 2004