Larry Cat In Space is a playful, imaginative cartoon presentation about an inquisitive cat who takes a trip to the Moon. Through Larry's eyes, we observe his human family, a group of enthusiastic sky-watchers. Larry notes how human time differs from cat time. Diana takes a job on the Moon, and sadly leaves Larry behind. Larry figures out a way to hide in her clothes trunk.
The trunk and Larry are loaded onto the Space Plane, which takes him to space station Freedom. From there, he is transferred to the Lunar Shuttle. During weightlessness, the trunk opens. Larry floats out into the cabin, and looks out the window. When Diana discovers Larry, he leaps to greet her, but sails over her head, since he only weighs two pounds in lunar gravity.
He meets the rest of Imbrium Village's inhabitants, including the evil Commander Stone, who orders Diana to return Larry to Earth. The Moon base crew petitions to keep Larry, and the Commander relents. He even makes Larry a cat space suit. When Larry ventures outside, he spots the Earth, looking a lot like the Moon did from the porch at home.