Tim Searls

Part-time Lecturer of Chemistry

Headshot of a man with white hair wearing a white shirt with a gray background.
(207)780-4232

161 Science Building, Portland Campus

Education

  • PhD, Biological Chemistry, Boston College
  • MST, Science Education, Boston College
  • BS, Chemistry, University of Massachusetts

Selected Publications

Synthesis of the analogue nucleoside 3-deaza-2′-deoxycytidine and its template activity with DNA polymerase

Searls, Tim; McLaughlin, Larry W.

Tetrahedron, 1999-10, Vol.55 (41), p.11985-11996

 

Nucleoside Analogue Substitutions in the Trinucleotide DNA Template Recognition Sequence 3‘-(CTG)-5‘ and Their Effects on the Activity of Bacteriophage T7 Primase

Searls, Tim; Chen, Dong Li; Lan, Tao; McLaughlin, Larry W

Biochemistry (Easton), 2000-04, Vol.39 (15), p.4375-4382

 

Anomalous Migration of Short Sequences of Nucleic Acids in Polyacrylamide Gels:  Prediction and Experiment

Mohanty, Udayan; Searls, Tim; McLaughlin, Larry W

Journal of the American Chemical Society, 1998-08, Vol.120 (32), p.8275-8276

 

Anomalous Migration of Short Sequences of DNA: Comparison of Theory and Experiment

Mohanty, Udayan; Searls, Tim; McLaughlin, Larry W.

Journal of Biomolecular Structure & Dynamics, 2000-01, Vol.17 (sup1), p.371-375

 

Migration Effects for Small Phosphate-Labeled Single-Stranded DNA Fragments in Gels:  Prediction and Experiment

Mohanty, Udayan; Searls, Tim; McLaughlin, Larry W

Journal of the American Chemical Society, 2000-02, Vol.122 (6), p.1225-1226

 

Evaluation of the Kinetic Properties of the Sporulation Protein SpoIIE of Bacillus subtilis by Inclusion in a Model Membrane

Searls, Tim; Chen, Xingyong; Allen, Stephanie; Yudkin, Michael D.

Journal of Bacteriology, 2004-05, Vol.186 (10), p.3195-3201

 

Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease

McDonough, Michael A.; Kavanagh, Kathryn L.; Butler, Danica; Searls, Timothy; Oppermann, Udo; Schofield, Christopher J.

The Journal of Biological Chemistry, 2005-12, Vol.280 (49), p.41101-41110

 

Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands

Searls, Timothy; Butler, Danica; Chien, Winnie; Mukherji, Mridul; Lloyd, Matthew D; Schofield, Christopher J

Journal of Lipid Research, 2005-08, Vol.46 (8), p.1660-1667

 

Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease

McDonough, Michael A.; Kavanagh, Kathryn L.; Butler, Danica; Searls, Timothy; Oppermann, Udo; Schofield, Christopher J.

The Journal of Biological Chemistry, 2005-12, Vol.280 (49), p.41101-41110

Headshot of a man with white hair wearing a white shirt with a gray background.
(207)780-4232

161 Science Building, Portland Campus

Education

  • PhD, Biological Chemistry, Boston College
  • MST, Science Education, Boston College
  • BS, Chemistry, University of Massachusetts